ANGL5_HUMAN
ID ANGL5_HUMAN Reviewed; 388 AA.
AC Q86XS5; A8K658; Q86VR9;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Angiopoietin-related protein 5;
DE AltName: Full=Angiopoietin-like protein 5;
DE Flags: Precursor;
GN Name=ANGPTL5; ORFNames=UNQ5795/PRO19600;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12624729; DOI=10.1007/s100380300025;
RA Zeng L., Dai J., Ying K., Zhao E., Jin W., Ye Y., Dai J., Xu J., Xie Y.,
RA Mao Y.;
RT "Identification of a novel human angiopoietin-like gene expressed mainly in
RT heart.";
RL J. Hum. Genet. 48:159-162(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86XS5; Q8N423: LILRB2; NbExp=5; IntAct=EBI-15485927, EBI-2816428;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in adult heart.
CC {ECO:0000269|PubMed:12624729}.
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DR EMBL; AY169281; AAO38749.1; -; mRNA.
DR EMBL; AY358827; AAQ89186.1; -; mRNA.
DR EMBL; AK291523; BAF84212.1; -; mRNA.
DR EMBL; AP003383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049170; AAH49170.1; -; mRNA.
DR CCDS; CCDS8312.1; -.
DR RefSeq; NP_835228.2; NM_178127.4.
DR AlphaFoldDB; Q86XS5; -.
DR SMR; Q86XS5; -.
DR BioGRID; 128996; 1.
DR DIP; DIP-59887N; -.
DR IntAct; Q86XS5; 3.
DR STRING; 9606.ENSP00000335255; -.
DR GlyGen; Q86XS5; 3 sites.
DR iPTMnet; Q86XS5; -.
DR PhosphoSitePlus; Q86XS5; -.
DR BioMuta; ANGPTL5; -.
DR DMDM; 296439430; -.
DR MassIVE; Q86XS5; -.
DR PaxDb; Q86XS5; -.
DR PeptideAtlas; Q86XS5; -.
DR PRIDE; Q86XS5; -.
DR Antibodypedia; 31728; 176 antibodies from 30 providers.
DR DNASU; 253935; -.
DR Ensembl; ENST00000334289.7; ENSP00000335255.3; ENSG00000187151.7.
DR GeneID; 253935; -.
DR KEGG; hsa:253935; -.
DR MANE-Select; ENST00000334289.7; ENSP00000335255.3; NM_178127.5; NP_835228.2.
DR UCSC; uc001pgl.3; human.
DR CTD; 253935; -.
DR DisGeNET; 253935; -.
DR GeneCards; ANGPTL5; -.
DR HGNC; HGNC:19705; ANGPTL5.
DR HPA; ENSG00000187151; Tissue enhanced (breast, ovary).
DR MIM; 607666; gene.
DR neXtProt; NX_Q86XS5; -.
DR OpenTargets; ENSG00000187151; -.
DR PharmGKB; PA134944139; -.
DR VEuPathDB; HostDB:ENSG00000187151; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000161966; -.
DR HOGENOM; CLU_038628_3_2_1; -.
DR InParanoid; Q86XS5; -.
DR OMA; HLDPLPY; -.
DR OrthoDB; 1034088at2759; -.
DR PhylomeDB; Q86XS5; -.
DR TreeFam; TF351983; -.
DR PathwayCommons; Q86XS5; -.
DR SignaLink; Q86XS5; -.
DR BioGRID-ORCS; 253935; 63 hits in 1061 CRISPR screens.
DR ChiTaRS; ANGPTL5; human.
DR GenomeRNAi; 253935; -.
DR Pharos; Q86XS5; Tbio.
DR PRO; PR:Q86XS5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86XS5; protein.
DR Bgee; ENSG00000187151; Expressed in calcaneal tendon and 77 other tissues.
DR ExpressionAtlas; Q86XS5; baseline and differential.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..388
FT /note="Angiopoietin-related protein 5"
FT /id="PRO_0000009127"
FT DOMAIN 141..383
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT COILED 98..123
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 310..314
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 324..338
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT VARIANT 175
FT /note="S -> P (in dbSNP:rs7946238)"
FT /id="VAR_055803"
FT CONFLICT 192
FT /note="R -> W (in Ref. 1; AAO38749, 2; AAQ89186, 3;
FT BAF84212 and 5; AAH49170)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="N -> S (in Ref. 1; AAO38749)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 388 AA; 44144 MW; 4060C998885151BF CRC64;
MMSPSQASLL FLNVCIFICG EAVQGNCVHH STDSSVVNIV EDGSNAKDES KSNDTVCKED
CEESCDVKTK ITREEKHFMC RNLQNSIVSY TRSTKKLLRN MMDEQQASLD YLSNQVNELM
NRVLLLTTEV FRKQLDPFPH RPVQSHGLDC TDIKDTIGSV TKTPSGLYII HPEGSSYPFE
VMCDMDYRGG GRTVIQKRID GIIDFQRLWC DYLDGFGDLL GEFWLGLKKI FYIVNQKNTS
FMLYVALESE DDTLAYASYD NFWLEDETRF FKMHLGRYSG NAGDAFRGLK KEDNQNAMPF
STSDVDNDGC RPACLVNGQS VKSCSHLHNK TGWWFNECGL ANLNGIHHFS GKLLATGIQW
GTWTKNNSPV KIKSVSMKIR RMYNPYFK
