ANGL7_MOUSE
ID ANGL7_MOUSE Reviewed; 337 AA.
AC Q8R1Q3;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Angiopoietin-related protein 7;
DE AltName: Full=Angiopoietin-like protein 7;
DE Flags: Precursor;
GN Name=Angptl7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=25622036; DOI=10.1371/journal.pone.0116838;
RA Toyono T., Usui T., Yokoo S., Taketani Y., Nakagawa S., Kuroda M.,
RA Yamagami S., Amano S.;
RT "Angiopoietin-like 7 is an anti-angiogenic protein required to prevent
RT vascularization of the cornea.";
RL PLoS ONE 10:E0116838-E0116838(2015).
CC -!- FUNCTION: Has a role in the formation and organization of the
CC extracellular matrix. In the eye, it functions as a mediator of
CC dexamethasone-induced matrix deposition in the trabecular meshwork, the
CC tissue responsible for the outflow of the ocular aqueous humor and for
CC the maintenance of intraocular pressure (By similarity). Is a negative
CC regulator of angiogenesis in the cornea, and plays a major role in
CC maintaining corneal avascularity and transparency (PubMed:25622036).
CC {ECO:0000250|UniProtKB:O43827, ECO:0000269|PubMed:25622036}.
CC -!- SUBUNIT: Homotetramer; disulfide-linked.
CC {ECO:0000250|UniProtKB:O43827}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O43827}.
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DR EMBL; AK031675; BAC27507.1; -; mRNA.
DR EMBL; BC023373; AAH23373.1; -; mRNA.
DR CCDS; CCDS18938.1; -.
DR RefSeq; NP_001034643.1; NM_001039554.3.
DR AlphaFoldDB; Q8R1Q3; -.
DR SMR; Q8R1Q3; -.
DR STRING; 10090.ENSMUSP00000030840; -.
DR GlyGen; Q8R1Q3; 4 sites.
DR iPTMnet; Q8R1Q3; -.
DR PhosphoSitePlus; Q8R1Q3; -.
DR MaxQB; Q8R1Q3; -.
DR PaxDb; Q8R1Q3; -.
DR PRIDE; Q8R1Q3; -.
DR ProteomicsDB; 296292; -.
DR Antibodypedia; 28091; 417 antibodies from 31 providers.
DR Ensembl; ENSMUST00000030840; ENSMUSP00000030840; ENSMUSG00000028989.
DR GeneID; 654812; -.
DR KEGG; mmu:654812; -.
DR UCSC; uc008vus.1; mouse.
DR CTD; 10218; -.
DR MGI; MGI:3605801; Angptl7.
DR VEuPathDB; HostDB:ENSMUSG00000028989; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000157064; -.
DR HOGENOM; CLU_038628_1_3_1; -.
DR InParanoid; Q8R1Q3; -.
DR OMA; DCASLYS; -.
DR OrthoDB; 357340at2759; -.
DR PhylomeDB; Q8R1Q3; -.
DR TreeFam; TF329953; -.
DR BioGRID-ORCS; 654812; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Angptl7; mouse.
DR PRO; PR:Q8R1Q3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R1Q3; protein.
DR Bgee; ENSMUSG00000028989; Expressed in tarsal region and 66 other tissues.
DR Genevisible; Q8R1Q3; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:1901346; P:negative regulation of vasculature development involved in avascular cornea development in camera-type eye; ISS:UniProtKB.
DR GO; GO:1903053; P:regulation of extracellular matrix organization; ISS:UniProtKB.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..337
FT /note="Angiopoietin-related protein 7"
FT /id="PRO_0000009132"
FT DOMAIN 113..334
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT COILED 30..110
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 244
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 122..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 276..289
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
SQ SEQUENCE 337 AA; 39014 MW; 1FCA16F99302A57E CRC64;
MLRETWLCVI LVAFVSHPVW LQKPHKRKTQ LKAAGCCEEM RELKAQVANL SSLLGELSRK
QESDWVSVVM QVMELESSSK HMESRLSTAE SKYSEMNNQI DIMQLQAAQT VTQTSADAIY
DCSSLYQKNY RISGVYKLPP DEFLGSPELE VFCDMETSGG GWTIIQRRKS GLVSFYQDWR
QYKQGFGSIR GDFWLGNEHI HRLTRQPSRL RVELEDWEGN ARYAEYSYFA LGNELNSYRL
FLGNYSGNVG KDALLYHNNT VFSTKDKDND NCLDKCAQLR KGGYWYNCCT DSNLNGVYYR
LGEHRKHMDG ISWYGWHGAN YSLKRVEMKI RPEAFKP
