ID   ANGLT_ROSHC             Reviewed;         473 AA.
AC   Q4R1I9;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Anthocyanidin 5,3-O-glucosyltransferase;
DE            EC=2.4.1.-;
DE   AltName: Full=UDP-glucose: anthocyanidin 5,3-O-glucosyltransferase;
GN   Name=RhGT1;
OS   Rosa hybrid cultivar.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Rosoideae incertae sedis;
OC   Rosa.
OX   NCBI_TaxID=128735;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=cv. Crimson Glory;
RX   PubMed=15944692; DOI=10.1038/nature435757a;
RA   Ogata J., Kanno Y., Itoh Y., Tsugawa H., Suzuki M.;
RT   "Plant biochemistry: anthocyanin biosynthesis in roses.";
RL   Nature 435:757-758(2005).
CC   -!- FUNCTION: Sequentially catalyzes two glycosylation steps at the 5-OH
CC       and 3-OH positions of anthocyanidin. Unglycosylated anthocyanidin or
CC       anthocyanidin 5-O-glucoside, but not anthocyanidin 3-O-glucoside, can
CC       be used as glucosyl acceptor. {ECO:0000269|PubMed:15944692}.
CC   -!- PATHWAY: Pigment biosynthesis; anthocyanin biosynthesis.
CC   -!- MISCELLANEOUS: In roses, anthocyanidin 3,5-O-diglucoside is the first
CC       stable anthocyanin, and therefore responsible for flower coloration,
CC       whereas this is usually anthocyanidin 3-O-glucoside in other plants.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=The color of the rose
CC       - Issue 63 of October 2005;
CC       URL="https://web.expasy.org/spotlight/back_issues/063";
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DR   EMBL; AB201048; BAD99560.1; -; mRNA.
DR   AlphaFoldDB; Q4R1I9; -.
DR   SMR; Q4R1I9; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PRIDE; Q4R1I9; -.
DR   KEGG; ag:BAD99560; -.
DR   UniPathway; UPA00009; -.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..473
FT                   /note="Anthocyanidin 5,3-O-glucosyltransferase"
FT                   /id="PRO_0000074172"
SQ   SEQUENCE   473 AA;  51877 MW;  F07504B331EBE2F8 CRC64;
     MGGDAIVLYP YPGLGHLISM VELGKLLLTH HPSFSITILA STAPTTIAAT AKLVASSNDQ
     LTNYIKAVSA DNPAINFHHL PTISSLPEHI EKLNLPFEYA RLQIPNILQV LQTLKSSLKA
     LILDMFCDAL FDVTKDLNIP TFYFYTSAGR SLAVLLNIPT FHRTTNSLSD FGDVPISISG
     MPPIPVSAMP KLLFDRSTNF YKSFLSTSTH MAKSNGIILN TFDLLEERAL KALRAGLCLP
     NQPTPPIFTV GPLISGKSGD NDEHESLKWL NNQPKDSVVF LCFGSMGVFS IKQLEAMALG
     LEKSGQRFLW VVRNPPIEEL PVEEPSLEEI LPKGFVERTK DRGLVVRKWA PQVEVLSHDS
     VGGFVTHCGW NSVLEAVCNG VPMVAWPLYA EQKLGRVFLV EEMKVAVGVK ESETGFVSAD
     ELEKRVRELM DSESGDEIRG RVSEFSNGGV KAKEEGGSSV ASLAKLAQLW KQK