ID   HEM3_CHLMU              Reviewed;         242 AA.
AC   Q9PK95;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable porphobilinogen deaminase;
DE            Short=PBG;
DE            EC=2.5.1.61;
DE   AltName: Full=Hydroxymethylbilane synthase;
DE            Short=HMBS;
DE   AltName: Full=Pre-uroporphyrinogen synthase;
GN   Name=hemC; OrderedLocusNames=TC_0572;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC       hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+);
CC         Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC   -!- SIMILARITY: Belongs to the HMBS family. {ECO:0000305}.
CC   -!- CAUTION: This sequence may not function as a hydroxymethylbilane
CC       synthase because it lacks the cysteine residue necessary for attachment
CC       of the dipyrromethane cofactor. {ECO:0000305}.
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DR   EMBL; AE002160; AAF39408.1; -; Genomic_DNA.
DR   PIR; E81688; E81688.
DR   RefSeq; WP_010230871.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PK95; -.
DR   SMR; Q9PK95; -.
DR   STRING; 243161.TC_0572; -.
DR   EnsemblBacteria; AAF39408; AAF39408; TC_0572.
DR   GeneID; 1245931; -.
DR   KEGG; cmu:TC_0572; -.
DR   eggNOG; COG0181; Bacteria.
DR   HOGENOM; CLU_019704_2_0_0; -.
DR   OMA; CDLAIHS; -.
DR   OrthoDB; 1450400at2; -.
DR   UniPathway; UPA00251; UER00319.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR000860; HemC.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   PANTHER; PTHR11557; PTHR11557; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
PE   3: Inferred from homology;
KW   Porphyrin biosynthesis; Transferase.
FT   CHAIN           1..242
FT                   /note="Probable porphobilinogen deaminase"
FT                   /id="PRO_0000143017"
SQ   SEQUENCE   242 AA;  27316 MW;  B8FDA863AEF7BCB9 CRC64;
     MLSAYYNDPF LSDFCLGKIP LRLASRKSPL AVLQAHECLR RLQTFFPRLW GQVITETTQG
     DLDQHTPLHS VENTGFFTDD IDFLVQSGKC DLAIHSAKDL PEKPKARVIA ITASIDPRDI
     LVFQEKYLLQ PFPSRLRIGC SSDRRRALIS SLYPSAVITD IRGTIQTRLA LLDQQKFDAI
     VMANAAVSRL GLRLPCTVVL PPPYHPFQGR LAITSCHHIA SWEKLFLTCK ITENINLLHF
     FS