ID   HEM3_CHLPN              Reviewed;         234 AA.
AC   Q9Z9C9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Probable porphobilinogen deaminase;
DE            Short=PBG;
DE            EC=2.5.1.61;
DE   AltName: Full=Hydroxymethylbilane synthase;
DE            Short=HMBS;
DE   AltName: Full=Pre-uroporphyrinogen synthase;
GN   Name=hemC; OrderedLocusNames=CPn_0052, CP_0723, CpB0053;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC       hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+);
CC         Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC   -!- SIMILARITY: Belongs to the HMBS family. {ECO:0000305}.
CC   -!- CAUTION: This sequence may not function as a hydroxymethylbilane
CC       synthase because it lacks the cysteine residue necessary for attachment
CC       of the dipyrromethane cofactor. {ECO:0000305}.
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DR   EMBL; AE001363; AAD18205.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38528.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98263.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP97986.1; -; Genomic_DNA.
DR   PIR; B72126; B72126.
DR   PIR; E86497; E86497.
DR   RefSeq; NP_224260.1; NC_000922.1.
DR   RefSeq; WP_010882702.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z9C9; -.
DR   SMR; Q9Z9C9; -.
DR   STRING; 115711.CP_0723; -.
DR   EnsemblBacteria; AAD18205; AAD18205; CPn_0052.
DR   EnsemblBacteria; AAF38528; AAF38528; CP_0723.
DR   GeneID; 45050096; -.
DR   KEGG; cpa:CP_0723; -.
DR   KEGG; cpj:hemC; -.
DR   KEGG; cpn:CPn_0052; -.
DR   KEGG; cpt:CpB0053; -.
DR   PATRIC; fig|115713.3.peg.60; -.
DR   eggNOG; COG0181; Bacteria.
DR   HOGENOM; CLU_019704_2_0_0; -.
DR   OrthoDB; 1450400at2; -.
DR   UniPathway; UPA00251; UER00319.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR000860; HemC.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   PANTHER; PTHR11557; PTHR11557; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
PE   3: Inferred from homology;
KW   Porphyrin biosynthesis; Transferase.
FT   CHAIN           1..234
FT                   /note="Probable porphobilinogen deaminase"
FT                   /id="PRO_0000143018"
SQ   SEQUENCE   234 AA;  26244 MW;  213F6FA7CCE6C3AD CRC64;
     MLSVCYSDPC LSDFCQGKRP LRIASRNSNL AKAQVHECIS LLRSWYPKLW FQLSTTETTG
     DREKKIPLHL VENSYFFTDG VDALVHKGVC DLAIHSAKDL PETPSLPVVA ITRCLHPADL
     LVYADHYVHE PLPLSPRLGS SSLRRSAVLK QLFPQGQILD IRGTIEERLD QLHRGHYDAI
     VLAKAASLRL HLHHAYSIEL PPPYHALQGS LAITAKDHAG KWKQLFTPIH CHSS