ID   ANI2_CAEEL              Reviewed;        1009 AA.
AC   Q09994;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Anillin-like protein 2;
GN   Name=ani-2; ORFNames=K10B2.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15930113; DOI=10.1242/dev.01828;
RA   Maddox A.S., Habermann B., Desai A., Oegema K.;
RT   "Distinct roles for two C. elegans anillins in the gonad and early
RT   embryo.";
RL   Development 132:2837-2848(2005).
CC   -!- FUNCTION: Required to maintain the structure of the rachis, the central
CC       cytoplasmic core of the syncytial adult gonad. Failure to maintain the
CC       rachis leads to premature dissociation of oocytes and thereby impedes
CC       oogenesis. {ECO:0000269|PubMed:15930113}.
CC   -!- TISSUE SPECIFICITY: Localizes to the surface of the rachis.
CC       {ECO:0000269|PubMed:15930113}.
CC   -!- DEVELOPMENTAL STAGE: Enriched in adults. {ECO:0000269|PubMed:15930113}.
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DR   EMBL; FO080748; CCD66397.1; -; Genomic_DNA.
DR   PIR; T16604; T16604.
DR   RefSeq; NP_495282.1; NM_062881.3.
DR   AlphaFoldDB; Q09994; -.
DR   SMR; Q09994; -.
DR   BioGRID; 39395; 2.
DR   IntAct; Q09994; 1.
DR   STRING; 6239.K10B2.5; -.
DR   iPTMnet; Q09994; -.
DR   EPD; Q09994; -.
DR   PaxDb; Q09994; -.
DR   PeptideAtlas; Q09994; -.
DR   PRIDE; Q09994; -.
DR   EnsemblMetazoa; K10B2.5.1; K10B2.5.1; WBGene00019608.
DR   GeneID; 174055; -.
DR   KEGG; cel:CELE_K10B2.5; -.
DR   UCSC; K10B2.5; c. elegans.
DR   CTD; 174055; -.
DR   WormBase; K10B2.5; CE02012; WBGene00019608; ani-2.
DR   eggNOG; KOG3640; Eukaryota.
DR   GeneTree; ENSGT00390000008749; -.
DR   HOGENOM; CLU_301150_0_0_1; -.
DR   InParanoid; Q09994; -.
DR   OMA; EYEEHDI; -.
DR   OrthoDB; 200480at2759; -.
DR   PhylomeDB; Q09994; -.
DR   Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR   Reactome; R-CEL-9013026; RHOB GTPase cycle.
DR   Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR   PRO; PR:Q09994; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00019608; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005826; C:actomyosin contractile ring; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0000915; P:actomyosin contractile ring assembly; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0008406; P:gonad development; IMP:WormBase.
DR   GO; GO:0000281; P:mitotic cytokinesis; IBA:GO_Central.
DR   GO; GO:0032504; P:multicellular organism reproduction; IMP:WormBase.
DR   GO; GO:0048477; P:oogenesis; IMP:WormBase.
DR   GO; GO:0030728; P:ovulation; IMP:WormBase.
DR   GO; GO:0031106; P:septin ring organization; IBA:GO_Central.
DR   GO; GO:0006949; P:syncytium formation; IMP:WormBase.
DR   CDD; cd01263; PH_anillin; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR012966; AHD.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037840; PH_Anillin.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF08174; Anillin; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Differentiation; Oogenesis;
KW   Reference proteome.
FT   CHAIN           1..1009
FT                   /note="Anillin-like protein 2"
FT                   /id="PRO_0000227970"
FT   DOMAIN          892..1005
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          626..657
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1009 AA;  115020 MW;  6B2D842697E7FAE3 CRC64;
     MYRRENINFS HPPQLKSPPP MSSPLDSNRS YRWTSLTAAN NSKFADTPVK ETPQKPDMSW
     WSPSRGDTWR LNAPRGRTLD LVAAFDQCSR QDQLDSPRYA NLGRYRRNSE PMQDNEKEVV
     TTNFIDDSMI EDHEEYEEHD IELGTDFYDP HMIRHHRSSE RFEQSLGTGQ QIETIHISTR
     LVPQLKRVPN SDYANDGRGD MKEYGSISKK NETPILDGTP KRPSPLTTRN IHKVDINRMD
     HLMKTENTVA GFITLTPQVS KVTHKSDFSK HFGQEESVRA SPMSRRNRRG TQTIVLPSFD
     SPASVRKSIP SPGLPTKTDI RSPSSLVKSI ANDFEKADFG FHRKIDAAEE IAQLRKRADN
     STFDENQNMV SDSAEDNVSN DFVPRISHLE MHPSVHMGIS GYAKKNHVPY GESNEEVLYS
     LPIKKQSRNV DREGMDQTDE ILLTPRAITM RQSLPFSDIP EERTCDKIDE MFDFVEVPTG
     DYDDKTTLER TVDGYAEVKS QKSPNKMIRN RLDLSTNTYQ EIEFEKDTTP YMQEFEEDGT
     GYSASSSGPQ FTRSPTLVTP HAGQSVAEYR VSDKEGCAKT EKVVVQKMSQ PSALATSTPK
     GTFAWRNKNQ SNAADDSFVS SISNFSAADK INDSKRQISK LIETIEKTRK HIQLAEISLI
     DAKRAQMVVQ ELASQRVLLI CRERLKLQLD EVRRLQALSV VRHPPPPINR HFKSAMVISN
     IAIHLNKNFN CRGSFAFIVA LKCRTEIEAT GVVTLLAHYQ TRMHVIHFGE HMHFSNLPVD
     FVIAMEVYMM RVPEYKAPEK TCAAVLAAKF RNLLVPNSAH RRARNNSVLS NRTVLSMPGY
     QAPDCDFRFC GKLTLDRDSA GDRQFYLDDV TYPLEGTVKL QSHCSSLPEA IDVEYRGFLY
     LFDERSPNGE AAWDRYWAML HRGIIFFWKN PIDEKNQKVP LSQIDLTKCT NQSVEETRNG
     RDHEFHIELL IDQTPSLLEK RRVVLAAESS DHLASWLNAI NDTLFVLRS