ANKAR_MOUSE
ID ANKAR_MOUSE Reviewed; 1465 AA.
AC A2RT91; Q8C0Q1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Ankyrin and armadillo repeat-containing protein;
GN Name=Ankar;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK030065; BAC26765.1; -; mRNA.
DR EMBL; BC132415; AAI32416.1; -; mRNA.
DR CCDS; CCDS15035.1; -.
DR RefSeq; NP_795954.2; NM_176980.4.
DR AlphaFoldDB; A2RT91; -.
DR SMR; A2RT91; -.
DR STRING; 10090.ENSMUSP00000054056; -.
DR iPTMnet; A2RT91; -.
DR PhosphoSitePlus; A2RT91; -.
DR PaxDb; A2RT91; -.
DR PRIDE; A2RT91; -.
DR ProteomicsDB; 282106; -.
DR Antibodypedia; 52164; 7 antibodies from 6 providers.
DR DNASU; 319695; -.
DR Ensembl; ENSMUST00000053499; ENSMUSP00000054056; ENSMUSG00000039342.
DR GeneID; 319695; -.
DR KEGG; mmu:319695; -.
DR UCSC; uc007bkt.2; mouse.
DR CTD; 150709; -.
DR MGI; MGI:2442559; Ankar.
DR VEuPathDB; HostDB:ENSMUSG00000039342; -.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00680000100065; -.
DR HOGENOM; CLU_006481_0_0_1; -.
DR InParanoid; A2RT91; -.
DR OMA; FMGLFKT; -.
DR OrthoDB; 81957at2759; -.
DR PhylomeDB; A2RT91; -.
DR TreeFam; TF324155; -.
DR BioGRID-ORCS; 319695; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Ankar; mouse.
DR PRO; PR:A2RT91; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; A2RT91; protein.
DR Bgee; ENSMUSG00000039342; Expressed in spermatocyte and 6 other tissues.
DR ExpressionAtlas; A2RT91; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 3.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR043379; ANKAR.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR46464; PTHR46464; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1465
FT /note="Ankyrin and armadillo repeat-containing protein"
FT /id="PRO_0000286807"
FT TRANSMEM 313..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 532..561
FT /note="ANK 1"
FT REPEAT 582..611
FT /note="ANK 2"
FT REPEAT 615..644
FT /note="ANK 3"
FT REPEAT 651..680
FT /note="ANK 4"
FT REPEAT 684..714
FT /note="ANK 5"
FT REPEAT 745..784
FT /note="ARM 1"
FT REPEAT 786..825
FT /note="ARM 2"
FT REPEAT 827..865
FT /note="ARM 3"
FT REPEAT 868..907
FT /note="ARM 4"
FT REPEAT 910..949
FT /note="ARM 5"
FT REPEAT 1085..1125
FT /note="ARM 6"
FT REGION 1431..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 533
FT /note="G -> D (in Ref. 1; BAC26765)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1465 AA; 165290 MW; BF1224D0F0A7049D CRC64;
MSRIVKKGIV KIDQEQDEET FRENLAVQRN ASAFFEKYDR TEVQELLTTT LVSWLAAKDD
ARSQLETPCG LMSQMNNAGF STAILLTPVD PTALLDYREV HQILRELAIG IYCLNQIPSI
SLEANFDQSS SCQLPPAYYD TRVGQILIQI DYMLKALWHG IYMPKEKRAR FSELWRTIMD
IDLDGKPQTT KNVFSEFSSA GLVDITNDPD FNGIYDEDMN EDPTYEPNSP EEKAVFMKYA
ESIMMKLTFS TVQIQQHENI FIFETAYWLS NAIKYNQDYL DICTYQRLQK RLYLQKKVIQ
KHFEKKKEIR RGMGYLKLIC FLIPFLLSLK RKMKVPYLNS LLPPFSDDKV KTERELPPFI
YGRDFKCQNF DYKQHQYFHV HGGIEFDIST HPVESALDEF KKNVEKIWEC ASSASAEDAG
YKEVYPIPVM ELNGKSYYVI HFELEIFYQQ LYKTQWWVAI NETVNNLKVK RLPLTEDQLH
EQFKKKFGLK KAMKCKSIPF GVKSAVERGL SAVFYTFSRK TSSSTINVSD EAGYAIFHHA
ALHNRVSVIC QLWSANFNVN QRRFIMFSQA DSSKVDMKKE RNGPTPLHLA AQACSLEATI
CLLCFKADYT LTEKRGWMPI HFAAFYDNIC ILIALCRKDP SLLEAEATAE NQCTPLLLAA
TSGALDTIQY LFSLGANWRK TDTKGNNIIH LSVLAFHTEV LKYIIELNIP ELPVWETLVE
MLQCESSKRR MMAVMSLEVI CLANDRYWQC ILDAGTIPAL VNLLKSPQIK LQYKTVGLLS
NISTHVSIVH AIVEAGGIPA VINLLTSDEP ELHSRCAIIL YDVAKCENKD VIAKYSGIPA
LINLLSLNKE SVLVNVMNCI RVLCMGNESN QQSMKDNNGI QYLIQFLSSD SDVLKALSSA
TIAEVARDNK EVQDAIAKEG AIPPLVTLFK GKQLSVQVKG AMAVESLANC NPLIQKEFLE
RELTKDLLKL LQAFQIDVKE QGAIALWALA GQTLKQQKYM AEQIGYNLII SMLLSPSAKM
QYVGGEAVIA LSKDSRMHQN QICEGKGIAP LVRLLRINKI PEGTLLSVIR AVGSICIGVA
HTSNPMSQQF VVEENALPVL IQLLRNHPSI NIRVEVAFSL ACIVLGNNSL KKELQNDEGF
EYSDVLYLLH SKDKEVCLKA GYALTLFAFN DRFQQHLILE TGLITVSIFE PFLQSSVETE
RAMAAFQIII LAKAIIDVEH VTLYGRGIQI LADSLNSVHA PTIALTGNII ASLAHSRAGI
PEAFVSLGTV QRLCYHLYAR SEEVRTACSC ALGYLTYNAH AFRLLLTECR NKPNQFLRIT
NNISKDAKIN PAFLKEFQLQ QRMGLPSLSL ERNGGPPVIP VFKKGKEHRQ KTRPKIQPRD
SLTLLPPVTN VKELFRTTHK ANISHNTFSF PSGVSSDIIN VSRPRIAFLN KLGKDEQKAN
PDPPAFLNKL GKDEQNANPD PAESQ
