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ANKAR_MOUSE
ID   ANKAR_MOUSE             Reviewed;        1465 AA.
AC   A2RT91; Q8C0Q1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Ankyrin and armadillo repeat-containing protein;
GN   Name=Ankar;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AK030065; BAC26765.1; -; mRNA.
DR   EMBL; BC132415; AAI32416.1; -; mRNA.
DR   CCDS; CCDS15035.1; -.
DR   RefSeq; NP_795954.2; NM_176980.4.
DR   AlphaFoldDB; A2RT91; -.
DR   SMR; A2RT91; -.
DR   STRING; 10090.ENSMUSP00000054056; -.
DR   iPTMnet; A2RT91; -.
DR   PhosphoSitePlus; A2RT91; -.
DR   PaxDb; A2RT91; -.
DR   PRIDE; A2RT91; -.
DR   ProteomicsDB; 282106; -.
DR   Antibodypedia; 52164; 7 antibodies from 6 providers.
DR   DNASU; 319695; -.
DR   Ensembl; ENSMUST00000053499; ENSMUSP00000054056; ENSMUSG00000039342.
DR   GeneID; 319695; -.
DR   KEGG; mmu:319695; -.
DR   UCSC; uc007bkt.2; mouse.
DR   CTD; 150709; -.
DR   MGI; MGI:2442559; Ankar.
DR   VEuPathDB; HostDB:ENSMUSG00000039342; -.
DR   eggNOG; KOG0507; Eukaryota.
DR   GeneTree; ENSGT00680000100065; -.
DR   HOGENOM; CLU_006481_0_0_1; -.
DR   InParanoid; A2RT91; -.
DR   OMA; FMGLFKT; -.
DR   OrthoDB; 81957at2759; -.
DR   PhylomeDB; A2RT91; -.
DR   TreeFam; TF324155; -.
DR   BioGRID-ORCS; 319695; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Ankar; mouse.
DR   PRO; PR:A2RT91; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; A2RT91; protein.
DR   Bgee; ENSMUSG00000039342; Expressed in spermatocyte and 6 other tissues.
DR   ExpressionAtlas; A2RT91; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 3.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR043379; ANKAR.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   PANTHER; PTHR46464; PTHR46464; 1.
DR   Pfam; PF00514; Arm; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1465
FT                   /note="Ankyrin and armadillo repeat-containing protein"
FT                   /id="PRO_0000286807"
FT   TRANSMEM        313..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          532..561
FT                   /note="ANK 1"
FT   REPEAT          582..611
FT                   /note="ANK 2"
FT   REPEAT          615..644
FT                   /note="ANK 3"
FT   REPEAT          651..680
FT                   /note="ANK 4"
FT   REPEAT          684..714
FT                   /note="ANK 5"
FT   REPEAT          745..784
FT                   /note="ARM 1"
FT   REPEAT          786..825
FT                   /note="ARM 2"
FT   REPEAT          827..865
FT                   /note="ARM 3"
FT   REPEAT          868..907
FT                   /note="ARM 4"
FT   REPEAT          910..949
FT                   /note="ARM 5"
FT   REPEAT          1085..1125
FT                   /note="ARM 6"
FT   REGION          1431..1465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        533
FT                   /note="G -> D (in Ref. 1; BAC26765)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1465 AA;  165290 MW;  BF1224D0F0A7049D CRC64;
     MSRIVKKGIV KIDQEQDEET FRENLAVQRN ASAFFEKYDR TEVQELLTTT LVSWLAAKDD
     ARSQLETPCG LMSQMNNAGF STAILLTPVD PTALLDYREV HQILRELAIG IYCLNQIPSI
     SLEANFDQSS SCQLPPAYYD TRVGQILIQI DYMLKALWHG IYMPKEKRAR FSELWRTIMD
     IDLDGKPQTT KNVFSEFSSA GLVDITNDPD FNGIYDEDMN EDPTYEPNSP EEKAVFMKYA
     ESIMMKLTFS TVQIQQHENI FIFETAYWLS NAIKYNQDYL DICTYQRLQK RLYLQKKVIQ
     KHFEKKKEIR RGMGYLKLIC FLIPFLLSLK RKMKVPYLNS LLPPFSDDKV KTERELPPFI
     YGRDFKCQNF DYKQHQYFHV HGGIEFDIST HPVESALDEF KKNVEKIWEC ASSASAEDAG
     YKEVYPIPVM ELNGKSYYVI HFELEIFYQQ LYKTQWWVAI NETVNNLKVK RLPLTEDQLH
     EQFKKKFGLK KAMKCKSIPF GVKSAVERGL SAVFYTFSRK TSSSTINVSD EAGYAIFHHA
     ALHNRVSVIC QLWSANFNVN QRRFIMFSQA DSSKVDMKKE RNGPTPLHLA AQACSLEATI
     CLLCFKADYT LTEKRGWMPI HFAAFYDNIC ILIALCRKDP SLLEAEATAE NQCTPLLLAA
     TSGALDTIQY LFSLGANWRK TDTKGNNIIH LSVLAFHTEV LKYIIELNIP ELPVWETLVE
     MLQCESSKRR MMAVMSLEVI CLANDRYWQC ILDAGTIPAL VNLLKSPQIK LQYKTVGLLS
     NISTHVSIVH AIVEAGGIPA VINLLTSDEP ELHSRCAIIL YDVAKCENKD VIAKYSGIPA
     LINLLSLNKE SVLVNVMNCI RVLCMGNESN QQSMKDNNGI QYLIQFLSSD SDVLKALSSA
     TIAEVARDNK EVQDAIAKEG AIPPLVTLFK GKQLSVQVKG AMAVESLANC NPLIQKEFLE
     RELTKDLLKL LQAFQIDVKE QGAIALWALA GQTLKQQKYM AEQIGYNLII SMLLSPSAKM
     QYVGGEAVIA LSKDSRMHQN QICEGKGIAP LVRLLRINKI PEGTLLSVIR AVGSICIGVA
     HTSNPMSQQF VVEENALPVL IQLLRNHPSI NIRVEVAFSL ACIVLGNNSL KKELQNDEGF
     EYSDVLYLLH SKDKEVCLKA GYALTLFAFN DRFQQHLILE TGLITVSIFE PFLQSSVETE
     RAMAAFQIII LAKAIIDVEH VTLYGRGIQI LADSLNSVHA PTIALTGNII ASLAHSRAGI
     PEAFVSLGTV QRLCYHLYAR SEEVRTACSC ALGYLTYNAH AFRLLLTECR NKPNQFLRIT
     NNISKDAKIN PAFLKEFQLQ QRMGLPSLSL ERNGGPPVIP VFKKGKEHRQ KTRPKIQPRD
     SLTLLPPVTN VKELFRTTHK ANISHNTFSF PSGVSSDIIN VSRPRIAFLN KLGKDEQKAN
     PDPPAFLNKL GKDEQNANPD PAESQ
 
 
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