ANKE1_MOUSE
ID ANKE1_MOUSE Reviewed; 775 AA.
AC Q9D2J7; Q0VB20;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Ankyrin repeat and EF-hand domain-containing protein 1;
DE AltName: Full=Ankyrin repeat domain-containing protein 5;
GN Name=Ankef1; Synonyms=Ankrd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK019547; BAB31791.1; -; mRNA.
DR EMBL; AK029804; BAC26624.1; -; mRNA.
DR EMBL; BC120825; AAI20826.1; -; mRNA.
DR CCDS; CCDS38249.1; -.
DR RefSeq; NP_783598.1; NM_175667.4.
DR AlphaFoldDB; Q9D2J7; -.
DR SMR; Q9D2J7; -.
DR STRING; 10090.ENSMUSP00000113881; -.
DR iPTMnet; Q9D2J7; -.
DR PhosphoSitePlus; Q9D2J7; -.
DR PaxDb; Q9D2J7; -.
DR PRIDE; Q9D2J7; -.
DR ProteomicsDB; 281981; -.
DR Antibodypedia; 35178; 100 antibodies from 15 providers.
DR DNASU; 319196; -.
DR Ensembl; ENSMUST00000028726; ENSMUSP00000028726; ENSMUSG00000074771.
DR Ensembl; ENSMUST00000121717; ENSMUSP00000113881; ENSMUSG00000074771.
DR Ensembl; ENSMUST00000180246; ENSMUSP00000135947; ENSMUSG00000074771.
DR GeneID; 319196; -.
DR KEGG; mmu:319196; -.
DR UCSC; uc008mom.1; mouse.
DR CTD; 63926; -.
DR MGI; MGI:2441685; Ankef1.
DR VEuPathDB; HostDB:ENSMUSG00000074771; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000156852; -.
DR HOGENOM; CLU_020261_0_0_1; -.
DR InParanoid; Q9D2J7; -.
DR OMA; EHKTPRA; -.
DR OrthoDB; 329492at2759; -.
DR PhylomeDB; Q9D2J7; -.
DR TreeFam; TF351260; -.
DR BioGRID-ORCS; 319196; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ankef1; mouse.
DR PRO; PR:Q9D2J7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D2J7; protein.
DR Bgee; ENSMUSG00000074771; Expressed in seminiferous tubule of testis and 61 other tissues.
DR ExpressionAtlas; Q9D2J7; baseline and differential.
DR Genevisible; Q9D2J7; MM.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..775
FT /note="Ankyrin repeat and EF-hand domain-containing protein
FT 1"
FT /id="PRO_0000066900"
FT REPEAT 47..76
FT /note="ANK 1"
FT REPEAT 184..213
FT /note="ANK 2"
FT REPEAT 217..246
FT /note="ANK 3"
FT REPEAT 250..279
FT /note="ANK 4"
FT REPEAT 524..553
FT /note="ANK 5"
FT REPEAT 557..586
FT /note="ANK 6"
FT REPEAT 590..619
FT /note="ANK 7"
FT REPEAT 623..652
FT /note="ANK 8"
SQ SEQUENCE 775 AA; 86904 MW; 51C11E1BC5151F00 CRC64;
MALADKRLEN LQIYRVLQCV RNKDKKQIEK LTRLGYPELI NFTEPIDGLS ALHLASISND
TDMVSFLLKL GAHPDVQDHM GCTPTMRAAE LGHELSMEIL AKAKADMTIV DNEGKGVLFY
CILPTKRHYR CSLIALEHGA DVNNITYEGK PVFLRACEEA HDVKDMCLTF LEKGANPNAI
NTSTGRTALM ESSREGVLEI VRGILERGGE VNAYDNDRHH AAHFAAKGGF FDILKLLFAY
NGDMGLIGMD GNTPLHFAAM GGFADCCKYI AQRGCDLKWK NLEHKTPRVV AKDGGFKAAS
KEIRRAERTA AKLAKTGAKN PNPLWALRLH DWSIEHETSL RNAFKFVDRG DGVVSKDDFV
VALEERQEYA TSEQLLSVAQ MHEKSRGGGV NINEFFKGTK YLSKSYVLGS FGPKKKKRGL
GKKPRKGKFV LPLPICTIPE NAFPRRPDGG PPYYMIETYQ NVSDSHRFNR DHPPEHPIQD
DSEWYIDDPS RVFANISFIT KAGDLASLKK AIETGIPVDM KDNTYKTPLM IACASGNIDV
VKFLIEKGAN VNATDNFLWT PLHFACHAGQ QDIVELLVKA GASIDATSIN NSTPLSRAIE
SCRLDTVKYL LDMGAKFQIE NRKGHAAMDI AKAYADYRII DMIKEKLDNL PKQADNQKMK
GKLPKLKTEG TDVKKEEETL SSIYTVPAIT EEKKVHRDSV VYLNSLITSG FTKKVDITFI
PKRIWSPEAT TAELIRKREL RRERFTYEVD FEDFMMPFQK NITEKAQALE ATLKN
