ANKHM_CAEBR
ID ANKHM_CAEBR Reviewed; 2636 AA.
AC Q60J38; A8WLA2; E3CTU8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 3.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Ankyrin repeat and KH domain-containing protein CBG24701;
GN ORFNames=CBG24701;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9VCA8}.
CC -!- SIMILARITY: Belongs to the mask family. {ECO:0000255}.
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DR EMBL; HE601238; CBX33004.1; -; Genomic_DNA.
DR AlphaFoldDB; Q60J38; -.
DR SMR; Q60J38; -.
DR STRING; 6238.CBG24701; -.
DR PRIDE; Q60J38; -.
DR WormBase; CBG24701a; CBP46150; WBGene00042750; -.
DR eggNOG; KOG4369; Eukaryota.
DR HOGENOM; CLU_000785_0_0_1; -.
DR InParanoid; Q60J38; -.
DR OMA; GWLEMER; -.
DR OrthoDB; 74671at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 7.
DR Gene3D; 3.30.1370.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF00013; KH_1; 1.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; SSF48403; 3.
DR SUPFAM; SSF54791; SSF54791; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 13.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 3: Inferred from homology;
KW ANK repeat; Coiled coil; Cytoplasm; Reference proteome; Repeat;
KW RNA-binding.
FT CHAIN 1..2636
FT /note="Ankyrin repeat and KH domain-containing protein
FT CBG24701"
FT /id="PRO_0000312831"
FT REPEAT 252..281
FT /note="ANK 1"
FT REPEAT 286..317
FT /note="ANK 2"
FT REPEAT 361..390
FT /note="ANK 3"
FT REPEAT 435..464
FT /note="ANK 4"
FT REPEAT 468..500
FT /note="ANK 5"
FT REPEAT 505..534
FT /note="ANK 6"
FT REPEAT 536..564
FT /note="ANK 7"
FT REPEAT 566..595
FT /note="ANK 8"
FT REPEAT 598..627
FT /note="ANK 9"
FT REPEAT 632..661
FT /note="ANK 10"
FT REPEAT 665..695
FT /note="ANK 11"
FT REPEAT 1273..1302
FT /note="ANK 12"
FT REPEAT 1306..1335
FT /note="ANK 13"
FT REPEAT 1340..1369
FT /note="ANK 14"
FT REPEAT 1373..1402
FT /note="ANK 15"
FT REPEAT 1408..1437
FT /note="ANK 16"
FT REPEAT 1447..1476
FT /note="ANK 17"
FT REPEAT 1480..1509
FT /note="ANK 18"
FT REPEAT 1515..1546
FT /note="ANK 19"
FT REPEAT 1548..1577
FT /note="ANK 20"
FT REPEAT 1581..1610
FT /note="ANK 21"
FT DOMAIN 1864..1929
FT /note="KH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT REGION 994..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1669..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1980..2182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2196..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2269..2292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2301..2320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2444..2465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2539..2636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1638..1696
FT /evidence="ECO:0000255"
FT COMPBIAS 1230..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1776
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..2013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2136..2159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2206..2221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2564..2636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2636 AA; 289786 MW; E1BF9113149AC950 CRC64;
MAHLIAFDHL IPFEMDLHNE ENPDYEEKRL RAFSTFYHFG AKLYECLRTV AVLMEEDGDS
MPVAEVLRHL GHEHLLSADI QYPPVAHIID VIEERCLDDT QVLFKISDLL EDHKLEKPED
FLPYSPDPQK IPVDVAADTV TAVASMCYHF LATSFSEEVM RMSSPETARD PIPLESECLK
LAIRTGSKKT ETIKISDAEP ESKPNYRHKP PVVSLELQQN AMLLLATRLG IEQFLILSKE
CGKLQFEGNH LSRITPLMEA AASSSEMIVE LLLDYGMDPN AQSVPNCNTA LIYAAATDDR
DMVEVILEHE GPHKVDVYLI NNYYRDAIME AAIGESLDTL SLFLEMGYEP KTLKEADETK
NDNSPLIFAA MKGFLDIATV ILDYQDKNQQ KTEEQTREIA EERYCALMEA AMEGQIAACK
LLILRGTPTE GFKSNLPSPM MLACAGGFPE LVEILLAAGA RIDETGPHKN TCLIEACDGV
SGDQVSVVRM LLNRHADVNA MNPESGDTPM SLAARHGNIA IMKMLYEKGA DLTTGKITPI
VEASIETHLE CVQFILAHCK TIPQEQLSRA LFAAAEGGCL KIVEELVRAG ADLNFEQDER
TAIMKAARFN HFDIVQYLVY KGASVNFKSA KNDATALSLA CTYGNMDIAQ FLIRNGADPM
LRMDDGVNCF MEAAKHGSFD LMKLLVEFTK GNMDLDKSPP KLGINRCKTN KKKKKSQLRF
QSSQILAMLN GKPSSERPFS STEADMFSHL LKCQQQMVEI NIDQSSDIIT DPTDVEFLQK
AVEGIQEAYG FTPEGQINFP RKPSKADMDS LYQGLLVPNI KMWAETIAHG WMTMERKVGR
PIEFNSFRIS PEVQIENALS AIQALTAVAS GLDNPAYLKS VFNKMNNGEE IPRVPATVGS
MNAASAALTG IGIHPDDALR LFAGNTFAKR AFRSSFFLLY HFSANPDDCV HEQYVAVHYM
QEGPFRAALL KLDSMYRERK GAAISVQNMV SNFPIDAHQS NPPPAQQTGP KTTSLTTPQP
DESNGATTIE HPTTPQIVFK SGGDKTMEAL DPMKVYPGVL KLAADMERLY RANQTDVSRE
IAVTTAYIAS TLPEKYSQEF NVESGDRILK RLLSGMSEKQ RAAVMTRVKS TINSESGTNL
LQRSVGTLSD KRLKEEYIKL FRETADTAFY DKSNRDKGSQ QLKAAEQKKG KTSAANVGSQ
VRLIFLIARS KLLILQISAA GKLLMGKPAN NTQVQQQQGQ QQQGQLRRTH SEGDGTERAK
ARSNVIDKAT DSTLETPLSI ACSNGHREVV ELLLKEGANI EHRDKKGFTP LIIAATYGHA
PIVEVLLKNH AAIEAQSDRT KDTALSLACT AGRKDVVEML LAHGANKEHR NVSDYTPLSL
ASSSGFLDIV NLLLTAGSEI NSRTGSKLGI SPLMLAAMNG HKETTKVLLE KGSDINAQIE
TNSYLFYRNT ALTLASFQGR FEVVKLLLCY NANVEHRAKT GLTPLMECAS GGYVDVGNLL
IENGADPNAS PVQSTKDTAL TIAAEKGHEK FVQMLLDNDV IYDIRNKKGC SALWLACNGG
HLGTAQALVF KGADTDMFDN RKMSPMVAAF RKGHIEIIKF LVGHAKQFPN ETDLVRMQST
LECADLVARC GECIIIIRNA KKAQAETAEE TANRLLQLID DEKERDINKK QKIKDKKKQK
KEAKKKFQAE QEQLSAPPSK PEPVVAPEPE PEPETEPVEE PAFEPTPPPV EEPPKEPPKP
RRNRRKTNPD GVPKGSKPAA EQAVKPPPPP VAEEEPEPAE LPYRPIVVKI PSPATVQAPM
MSPGSYSESE DWQKAGKEGK KVRPKREGRG TAPSSAGSSQ AKHRSNTSSI SERQHSWEVD
TKGVKAYEFT VPGKIVSRVI GKSGSNINAV REATLAQIEI DKLCGSKEDD RHITVRGSAD
VVSMAVNIIH LLIYDKDVLI HDAIRTATHG NVSVASSLSS EGTSKSAVDS THSIPHSLSS
ASIARQSSPV PVPSQCNRSS KSHGNQATKD GANVWQQRMA ARGETPPTQT QTKQQPTPSP
QVQQPARQTA SPAVRQSLAQ SSVPQATENV TKPTQTPPAS VQQPIDRVIA PPARREPAQV
VQPVPPVHQH TPVPQQRPQE VAQPPRFPDP ISRPAVSLQQ HMQQIQQQPT FSKAPGTRLS
NEFSRAPGPP VQPQTPPQSL PSRNDVFEDR LPFTAFKPTA PAPAPVTSIA PSTSTATSTA
SNGATLDDFD ISKLRMYEDS RVQSIWGTDR TNGEEDTWGG LFTNLLQPNS TASSLNTATT
KNDTSDWGSN DFMSQLLAGT SNQKTSSAPQ QPVSSVNSQL SALETKGWMP STATPPTARD
PVQRQVPLFA RSQSSNPSTL QHQQQQQRIM QDPHQSHLHQ VMQQQHHSRI PQQFQQPQFS
SQSHPSQSSM MPSTQQQLLS QLQAMNLGQQ GSNPYDMLAH QLSMHRQENS SSVPGPSQPS
ANPYYSPSYT DSSVLGQLNM NTLSQRGIKQ FDGFNNDQSQ SSDGVIAALF NEQQQQKKNQ
QAGYMQQGQQ SFGSTQRIGM MQPAPPPFVP QQAPGAPPGF GDLNRSASGS SQNRPMYPGY
GAQQPQPFSQ LTQADWDQRL LLQQQQQQRS SQQQQNPTNQ GLPQKWSNTW NSSSRM
