ANKH_RAT
ID ANKH_RAT Reviewed; 492 AA.
AC P58366;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Progressive ankylosis protein homolog;
DE Short=ANK;
GN Name=Ankh; Synonyms=Ank;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Miyashiro K., Finnell R.H., Eberwine J.;
RT "Rat progressive ankylosis gene/termesin.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates intra- and extracellular levels of inorganic
CC pyrophosphate (PPi), probably functioning as PPi transporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ANKH family. {ECO:0000305}.
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DR EMBL; AF393241; AAK73750.1; -; mRNA.
DR RefSeq; NP_446166.1; NM_053714.1.
DR AlphaFoldDB; P58366; -.
DR SMR; P58366; -.
DR STRING; 10116.ENSRNOP00000060060; -.
DR jPOST; P58366; -.
DR PaxDb; P58366; -.
DR GeneID; 114506; -.
DR KEGG; rno:114506; -.
DR UCSC; RGD:619925; rat.
DR CTD; 56172; -.
DR RGD; 619925; Ankh.
DR eggNOG; ENOG502QWCU; Eukaryota.
DR InParanoid; P58366; -.
DR OrthoDB; 484099at2759; -.
DR PhylomeDB; P58366; -.
DR Reactome; R-RNO-5223345; Miscellaneous transport and binding events.
DR PRO; PR:P58366; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030504; F:inorganic diphosphate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0110148; P:biomineralization; ISO:RGD.
DR GO; GO:0030282; P:bone mineralization; ISO:RGD.
DR GO; GO:0055074; P:calcium ion homeostasis; ISO:RGD.
DR GO; GO:0071529; P:cementum mineralization; ISO:RGD.
DR GO; GO:0071344; P:diphosphate metabolic process; ISO:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0030505; P:inorganic diphosphate transport; ISO:RGD.
DR GO; GO:0055062; P:phosphate ion homeostasis; ISO:RGD.
DR GO; GO:0006817; P:phosphate ion transport; TAS:RGD.
DR GO; GO:0030500; P:regulation of bone mineralization; ISS:UniProtKB.
DR GO; GO:1904383; P:response to sodium phosphate; ISO:RGD.
DR InterPro; IPR009887; ANKH.
DR PANTHER; PTHR28384; PTHR28384; 1.
DR Pfam; PF07260; ANKH; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphate transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..492
FT /note="Progressive ankylosis protein homolog"
FT /id="PRO_0000137469"
FT TOPO_DOM 1..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..350
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..403
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 453..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 458..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54265 MW; 99CAC27641A2EC0B CRC64;
MVKFPALTHY WPLIRFLVPL GITNIAIDFG EQALNRGIAA VKEDAVEMLA SYGLAYSLMK
FFAGPMSDFK NVGLVFVNSK RDRAKAVLCM VVAGAIAAVF HTLIAYSDLG YYIINKLHHV
DESVGSKTRR AFLYLAAFPF MDAMAWTHAG ILLKHKYSFL VGCASISDVI AQVVFVAILL
HSHLECREPL LIPILSLYMG ALVRCTTLCL GYYRNIHDII PDRSGPELGG DATIRKMLSF
WWPLALILAT QRISRPIVNL FVSRDLGGSS AATEAVAILT ATYPVGHMPY GWLTEIRAVY
PAFDKNNPSN KLANTNNTVT SAHIKKFTFV CMALSLTLCF VMFWTPNVSE KILIDIIGVD
FAFAELCVIP LRIFSFFPVP VTVRAHLTGW LMTLKKTFVL APSSVLRIIV LITSLVVLPY
LGVHGATLGV GSLLAGFVGE STMVALAACY VYRKQKKKME NESATEGEDS AMTDMPPAEE
VTDIVEMREE NE
