ID   HEM4_ARCFU              Reviewed;         226 AA.
AC   O30120;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Putative uroporphyrinogen-III synthase;
DE            Short=UROS;
DE            EC=4.2.1.75;
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE   AltName: Full=Uroporphyrinogen-III cosynthase;
GN   OrderedLocusNames=AF_0116;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000782; AAB91112.1; -; Genomic_DNA.
DR   PIR; D69264; D69264.
DR   RefSeq; WP_010877630.1; NC_000917.1.
DR   AlphaFoldDB; O30120; -.
DR   SMR; O30120; -.
DR   STRING; 224325.AF_0116; -.
DR   EnsemblBacteria; AAB91112; AAB91112; AF_0116.
DR   GeneID; 24793670; -.
DR   KEGG; afu:AF_0116; -.
DR   eggNOG; arCOG02048; Archaea.
DR   HOGENOM; CLU_011276_9_5_2; -.
DR   OMA; FTSSMMV; -.
DR   OrthoDB; 102188at2157; -.
DR   PhylomeDB; O30120; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR40082; PTHR40082; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; SSF69618; 1.
PE   3: Inferred from homology;
KW   Lyase; Porphyrin biosynthesis; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Putative uroporphyrinogen-III synthase"
FT                   /id="PRO_0000135248"
SQ   SEQUENCE   226 AA;  25856 MW;  8BB11FDA86D3D1AD CRC64;
     MKVLILRPAE LLSETIRRFR EEGFDAYGCP FIKLIYTDFD VPEHDFAIVT SQNAARVLRE
     RGVRLKRVIA IGKKTAELIE AEEVLLPSKF DSETLYEEFA EMLRGKRVVA FRSNAGSEAV
     KRLSEVADFR EIQVYRIEKL QGEEQRREVE KVREGFYDAI VFSSSMIARS LLELCDEKCL
     EALKNIFVVA IGPPTAKVLA EKGIRAEIPE EYTFDGVIEL LKSKKM