HEM4_CHLP8
ID HEM4_CHLP8 Reviewed; 246 AA.
AC Q59335; B3QMK0; Q59333;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Uroporphyrinogen-III synthase;
DE Short=UROS;
DE EC=4.2.1.75;
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE AltName: Full=Uroporphyrinogen-III cosynthase;
GN Name=hemD; OrderedLocusNames=Cpar_0736;
OS Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) (Chlorobium vibrioforme
OS subsp. thiosulfatophilum).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX NCBI_TaxID=517417;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Majumdar D., Wyche J.H.;
RL Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 263 / NCIMB 8327;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z., Overmann J.,
RA Bryant D.A., Richardson P.;
RT "Complete sequence of Chlorobaculum parvum NCIB 8327.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-246.
RX PubMed=8626508; DOI=10.1074/jbc.271.14.8176;
RA Rhie G.-E., Avissar Y.J., Beale S.I.;
RT "Structure and expression of the Chlorobium vibrioforme hemB gene and
RT characterization of its encoded enzyme, porphobilinogen synthase.";
RL J. Biol. Chem. 271:8176-8182(1996).
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M96364; AAA23114.1; -; Genomic_DNA.
DR EMBL; CP001099; ACF11153.1; -; Genomic_DNA.
DR EMBL; U38348; AAC43974.1; -; Genomic_DNA.
DR RefSeq; WP_012501986.1; NC_011027.1.
DR AlphaFoldDB; Q59335; -.
DR SMR; Q59335; -.
DR STRING; 517417.Cpar_0736; -.
DR EnsemblBacteria; ACF11153; ACF11153; Cpar_0736.
DR KEGG; cpc:Cpar_0736; -.
DR eggNOG; COG1587; Bacteria.
DR HOGENOM; CLU_011276_9_5_10; -.
DR OMA; VWAVGKT; -.
DR OrthoDB; 1185397at2; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000008811; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; PTHR38042; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; SSF69618; 1.
PE 3: Inferred from homology;
KW Lyase; Porphyrin biosynthesis.
FT CHAIN 1..246
FT /note="Uroporphyrinogen-III synthase"
FT /id="PRO_0000135242"
SQ SEQUENCE 246 AA; 26786 MW; 58DA229096BCCE1C CRC64;
MKTVLVTRPK HQAAPFVREL EQYGLSTVVF PTIEIRPVAG WNVPDLTKFA GIFFTSPNSV
QFFLKHLLQT APDELKNLQQ TRVWAVGKTT GQDLEKHGVS IEPLPKIADA VNLMADIDPA
EIKGQTFLFV RGSLSLGTIP ELIAEFGGTC VELTVYENLP PSLEDTQRVK DMLAEGKLDC
LSFTSPSTAK NFFEAIGSKE LSDSVQIAAI GTTTSGALEK MGIKVDIIPE YFDGPSFAKA
IAEALK
