ID   HEM4_CHLTE              Reviewed;         246 AA.
AC   Q8KCJ3;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Uroporphyrinogen-III synthase;
DE            Short=UROS;
DE            EC=4.2.1.75;
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE   AltName: Full=Uroporphyrinogen-III cosynthase;
GN   Name=hemD; OrderedLocusNames=CT1428;
OS   Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
OS   (Chlorobium tepidum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX   NCBI_TaxID=194439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / NBRC 103806 / TLS;
RX   PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J.,
RA   DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D.,
RA   Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M.,
RA   Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V.,
RA   Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M.,
RA   White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A.,
RA   Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic,
RT   anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AE006470; AAM72656.1; -; Genomic_DNA.
DR   RefSeq; NP_662314.1; NC_002932.3.
DR   RefSeq; WP_010933095.1; NC_002932.3.
DR   AlphaFoldDB; Q8KCJ3; -.
DR   SMR; Q8KCJ3; -.
DR   STRING; 194439.CT1428; -.
DR   EnsemblBacteria; AAM72656; AAM72656; CT1428.
DR   KEGG; cte:CT1428; -.
DR   PATRIC; fig|194439.7.peg.1296; -.
DR   eggNOG; COG1587; Bacteria.
DR   HOGENOM; CLU_011276_9_5_10; -.
DR   OMA; VWAVGKT; -.
DR   OrthoDB; 1185397at2; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000001007; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; PTHR38042; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; SSF69618; 1.
PE   3: Inferred from homology;
KW   Lyase; Porphyrin biosynthesis; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Uroporphyrinogen-III synthase"
FT                   /id="PRO_0000135241"
SQ   SEQUENCE   246 AA;  26616 MW;  E45E4C7BA7F75AC0 CRC64;
     MKTVLVTRPK HQAEPFVREL AQYGLDSVVF PTIEIRPVTG WSVPDLTRFA GIFFTSPNSV
     QFFLERLLEE SPDELPNLQQ ARVWAVGKTT GGDLEKHGVS IEPLPKSADA VSLMSGIDAS
     EIEGKTFLFV RGSLSLGTIP EVIAKRGGIC VELTVYDNIQ PSLEETQKIK SLLTEGKIDC
     LSFTSPSTAI NFFEAIDSKE VPSDVLIAAI GTTTSSALEK LGVKVDIIPE YFDGPNFAKA
     IAAALS