ID   HEM4_METJA              Reviewed;         240 AA.
AC   Q58401;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Putative uroporphyrinogen-III synthase;
DE            Short=UROS;
DE            EC=4.2.1.75;
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE   AltName: Full=Uroporphyrinogen-III cosynthase;
GN   Name=hemD; OrderedLocusNames=MJ0994;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98999.1; -; Genomic_DNA.
DR   PIR; B64424; B64424.
DR   RefSeq; WP_010870508.1; NC_000909.1.
DR   AlphaFoldDB; Q58401; -.
DR   SMR; Q58401; -.
DR   STRING; 243232.MJ_0994; -.
DR   EnsemblBacteria; AAB98999; AAB98999; MJ_0994.
DR   GeneID; 1451892; -.
DR   KEGG; mja:MJ_0994; -.
DR   eggNOG; arCOG02048; Archaea.
DR   HOGENOM; CLU_011276_9_5_2; -.
DR   InParanoid; Q58401; -.
DR   OMA; VWAVGKT; -.
DR   OrthoDB; 106625at2157; -.
DR   PhylomeDB; Q58401; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IBA:GO_Central.
DR   GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IBA:GO_Central.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; PTHR38042; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; SSF69618; 1.
PE   3: Inferred from homology;
KW   Lyase; Porphyrin biosynthesis; Reference proteome.
FT   CHAIN           1..240
FT                   /note="Putative uroporphyrinogen-III synthase"
FT                   /id="PRO_0000135249"
SQ   SEQUENCE   240 AA;  27614 MW;  F0AA2E8CCEF9BAE8 CRC64;
     MKVVITRPKE RADVFASLLK KEGFEPIIFP TLEIVYNKDL DVNLDSYDWI AFTSPSGVIG
     LYNILTENER ENVKNKKIAV IGEKTAKTFK KYFGRDPDIM PNEYTAESLL REIKKVSKEE
     EKFLIPTTPS TRDVLKNNLN ADLLFVYKSA EPENLKEDIK KLKELIAKDK FILTFTSGLT
     AKNFFKYVDD EFAEIIKDNY IVAIGPITAK VIEKFGFKPL IPKVYTIEGM LEVIRTLKER