HEM4_METTH
ID HEM4_METTH Reviewed; 253 AA.
AC O26268;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Putative uroporphyrinogen-III synthase;
DE Short=UROS;
DE EC=4.2.1.75;
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE AltName: Full=Uroporphyrinogen-III cosynthase;
GN Name=hemD; OrderedLocusNames=MTH_166;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000305}.
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DR EMBL; AE000666; AAB84672.1; -; Genomic_DNA.
DR PIR; H69088; H69088.
DR AlphaFoldDB; O26268; -.
DR SMR; O26268; -.
DR STRING; 187420.MTH_166; -.
DR EnsemblBacteria; AAB84672; AAB84672; MTH_166.
DR KEGG; mth:MTH_166; -.
DR PATRIC; fig|187420.15.peg.139; -.
DR HOGENOM; CLU_011276_9_5_2; -.
DR OMA; VWAVGKT; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR40082; PTHR40082; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; SSF69618; 1.
PE 3: Inferred from homology;
KW Lyase; Porphyrin biosynthesis; Reference proteome.
FT CHAIN 1..253
FT /note="Putative uroporphyrinogen-III synthase"
FT /id="PRO_0000135250"
SQ SEQUENCE 253 AA; 27462 MW; D3B0A791369A4F3E CRC64;
MAVTRPPERS AEAVELIEGA GGRALVAPTL ELKEAHTESL REVCRRADEW DLVIFTSQAA
VESLFQLCRE FAGKIRKDCL VAVIGPRTAR VAGEHGLRVD IVPEDYTAEG LLDALTGLNI
EGWKVALPRT LSARKVLPRG LEMMGAEVLV AEAYRSGLPE DTGPAEELID GLLDGKVDAV
TFTSPLTVEN LFKIAGNRRK ELIEVLKRVK VAAIGPITLR KLEEHGITAV TPERYTVKDM
IAALAVSMGE DVD
