ID   ANKH_TETNG              Reviewed;         487 AA.
AC   P58369; Q4RMZ7;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Progressive ankylosis protein homolog;
DE            Short=ANK;
GN   Name=ankh; ORFNames=GSTENG00031805001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 67-421.
RC   TISSUE=Muscle;
RX   PubMed=11326272; DOI=10.1038/ng0501-37;
RA   Nuernberg P., Thiele H., Chandler D., Hoehne W., Cunningham M.L.,
RA   Ritter H., Leschik G., Uhlmann K., Mischung C., Harrop K., Goldblatt J.,
RA   Borochowitz Z.U., Kotzot D., Westermann F., Mundlos S., Braun H.-S.,
RA   Laing N., Tinschert S.;
RT   "Heterozygous mutations in ANKH, the human ortholog of the mouse
RT   progressive ankylosis gene, result in craniometaphyseal dysplasia.";
RL   Nat. Genet. 28:37-41(2001).
CC   -!- FUNCTION: Regulates intra- and extracellular levels of inorganic
CC       pyrophosphate (PPi), probably functioning as PPi transporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANKH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG10235.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CAAE01015017; CAG10235.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AJ302034; CAC40964.1; -; mRNA.
DR   AlphaFoldDB; P58369; -.
DR   SMR; P58369; -.
DR   STRING; 99883.ENSTNIP00000020270; -.
DR   KEGG; tng:GSTEN00031805G001; -.
DR   InParanoid; P58369; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR009887; ANKH.
DR   PANTHER; PTHR28384; PTHR28384; 1.
DR   Pfam; PF07260; ANKH; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..487
FT                   /note="Progressive ankylosis protein homolog"
FT                   /id="PRO_0000137472"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  53494 MW;  8B6F0F0CBE97D7BD CRC64;
     MVEFPSLSPY WPLIRFLVPL AITNVAIDLG EQALNRGIAT VKEDAVEMLA SYGLAYSLMK
     FFTGPLSDFK NVGLVFVNSK RDRRKAMFLL VTAGVTAFVL HILIAYTDLG YYIINKLHHV
     DESVGGKTRK AFLFLAAFPL LDALAWIHAG ILLKHKYSLI VGSASISDVV AQIVFVAILL
     HSNLECAEPL LIPILSLYMG ALVRFTIVGL GYYCNIHDNI PDTSGLDVGG DATIKKMLSF
     WWPLALILAT QRISRPIVNL FVSRDLKGTS EATEAVAVLT ATYPVGHMPY GWLTELRAVY
     PAFDKNNPSN KINASSPVTK SHIKKFTFCC LALSLMLCFV LFWTPHVSEK ILVDVIGVDY
     AFAELCVVPL RIFSFFPLPV TLRAHLTAWL MTLKKTFVLA PSSVLRIIVL ITSLVVLPYM
     GVHGATLGVG SLLAGFVGES TMVAIAACYV YRRQVSSPGW TQQLLTVYPS SVGRGSLLIR
     SKQLCLS