ID   HEM4_PROMI              Reviewed;         199 AA.
AC   Q59683;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Uroporphyrinogen-III synthase;
DE            Short=UROS;
DE            EC=4.2.1.75;
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE   AltName: Full=Uroporphyrinogen-III cosynthase;
GN   Name=hemD;
OS   Proteus mirabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=584;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8874804; DOI=10.1016/0300-9084(96)82192-4;
RA   Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.;
RT   "Comparative analysis of the cya locus in enterobacteria and related Gram-
RT   negative facultative anaerobes.";
RL   Biochimie 78:277-287(1996).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000305}.
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DR   EMBL; U22969; AAC44328.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q59683; -.
DR   SMR; Q59683; -.
DR   STRING; 584.AOUC001_17910; -.
DR   UniPathway; UPA00251; UER00320.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; PTHR38042; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; SSF69618; 1.
PE   3: Inferred from homology;
KW   Lyase; Porphyrin biosynthesis.
FT   CHAIN           1..199
FT                   /note="Uroporphyrinogen-III synthase"
FT                   /id="PRO_0000135244"
SQ   SEQUENCE   199 AA;  22799 MW;  4CC1CC06C26D31BA CRC64;
     MSILITRPSP AGEQLTQRLI DAGKHAFHAP LIEIAAGKEL SILENKLNKL STGDYLFLLS
     KNAVWYANWQ LNQLQQSWPD TLFYYGIGQS TAEEFQQLTA HSIRYPEFGE TSEDLLALSS
     LQQIENKRVL LLRGNGGREL LATTLRQRGA IVDECECYQR LFIDYVSEEF ALKWKNAQVE
     YLCGHQCEML QQLLSSRWI