ID   HEM4_SALTY              Reviewed;         246 AA.
AC   Q9L6Q3;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Uroporphyrinogen-III synthase;
DE            Short=UROS;
DE            EC=4.2.1.75;
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE   AltName: Full=Uroporphyrinogen-III cosynthase;
GN   Name=hemD; OrderedLocusNames=STM3937; ORFNames=STMD1.54;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AF233324; AAF33454.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22782.1; -; Genomic_DNA.
DR   RefSeq; NP_462823.1; NC_003197.2.
DR   RefSeq; WP_000025498.1; NC_003197.2.
DR   AlphaFoldDB; Q9L6Q3; -.
DR   SMR; Q9L6Q3; -.
DR   STRING; 99287.STM3937; -.
DR   PaxDb; Q9L6Q3; -.
DR   DNASU; 1255463; -.
DR   EnsemblBacteria; AAL22782; AAL22782; STM3937.
DR   GeneID; 1255463; -.
DR   KEGG; stm:STM3937; -.
DR   PATRIC; fig|99287.12.peg.4154; -.
DR   HOGENOM; CLU_011276_9_4_6; -.
DR   OMA; HPRIAQA; -.
DR   PhylomeDB; Q9L6Q3; -.
DR   BioCyc; SENT99287:STM3937-MON; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; PTHR38042; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; SSF69618; 1.
PE   3: Inferred from homology;
KW   Lyase; Porphyrin biosynthesis; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Uroporphyrinogen-III synthase"
FT                   /id="PRO_0000135246"
SQ   SEQUENCE   246 AA;  27662 MW;  AB28397040404C22 CRC64;
     MSILITRPSP AGEALVSRLR ALGQVAWSFP LIEFVAGREL PTLADRLATL TENDLVFALS
     QHAVAFAHAQ LQRDGRNWPV APRYFAIGRT TALALHTVSG FDIRYPLDRE ISEALLQLPE
     LQNIAGKRAL ILRGNGGREL LGETLTARGA EVSFCECYQR CAKHYDGAEE AMRWHTRGVT
     TLVVTSGEML QRLWSLTPQW YREHWLLRCR LLVVSERLAH LARELGWQDI KVADNADNDA
     LLRALQ