HEM4_SYNE7
ID HEM4_SYNE7 Reviewed; 264 AA.
AC P42452; Q31RL5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Uroporphyrinogen-III synthase;
DE Short=UROS;
DE EC=4.2.1.75;
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing];
DE AltName: Full=Uroporphyrinogen-III cosynthase;
GN Name=hemD; OrderedLocusNames=Synpcc7942_0272;
OS Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS R2).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8123787; DOI=10.1007/bf00024112;
RA Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.;
RT "Cloning and characterisation of genes for tetrapyrrole biosynthesis from
RT the cyanobacterium Anacystis nidulans R2.";
RL Plant Mol. Biol. 24:435-448(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000305}.
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DR EMBL; X70966; CAA50303.1; -; Genomic_DNA.
DR EMBL; CP000100; ABB56304.1; -; Genomic_DNA.
DR RefSeq; WP_011243553.1; NC_007604.1.
DR AlphaFoldDB; P42452; -.
DR SMR; P42452; -.
DR STRING; 1140.Synpcc7942_0272; -.
DR PRIDE; P42452; -.
DR DNASU; 3773834; -.
DR EnsemblBacteria; ABB56304; ABB56304; Synpcc7942_0272.
DR KEGG; syf:Synpcc7942_0272; -.
DR eggNOG; COG1587; Bacteria.
DR HOGENOM; CLU_011276_9_5_3; -.
DR OMA; VWAVGKT; -.
DR OrthoDB; 1185397at2; -.
DR BioCyc; SYNEL:SYNPCC7942_0272-MON; -.
DR UniPathway; UPA00251; UER00320.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; PTHR38042; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; SSF69618; 1.
PE 3: Inferred from homology;
KW Lyase; Porphyrin biosynthesis.
FT CHAIN 1..264
FT /note="Uroporphyrinogen-III synthase"
FT /id="PRO_0000135247"
SQ SEQUENCE 264 AA; 28196 MW; 0BAB84E9F86E80FA CRC64;
MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP LDEAIAAIAD
FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT AQVLAAQGGK ADYIPPEFIA
ESLVEHFPQP VAGQRLLFPR VETGGREQIT QALQSQGAIV VEVPAYESRC PSQIPDDALI
ALRQAHLNLI SFTSSKTVRN FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV
EVEAQEYTLD GLLLAIEQWA RQTT
