ID   ANKH_XENLA              Reviewed;         492 AA.
AC   P58367;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Progressive ankylosis protein homolog;
DE            Short=ANK;
GN   Name=ankh;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11326272; DOI=10.1038/ng0501-37;
RA   Nuernberg P., Thiele H., Chandler D., Hoehne W., Cunningham M.L.,
RA   Ritter H., Leschik G., Uhlmann K., Mischung C., Harrop K., Goldblatt J.,
RA   Borochowitz Z.U., Kotzot D., Westermann F., Mundlos S., Braun H.-S.,
RA   Laing N., Tinschert S.;
RT   "Heterozygous mutations in ANKH, the human ortholog of the mouse
RT   progressive ankylosis gene, result in craniometaphyseal dysplasia.";
RL   Nat. Genet. 28:37-41(2001).
CC   -!- FUNCTION: Regulates intra- and extracellular levels of inorganic
CC       pyrophosphate (PPi), probably functioning as PPi transporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ANKH family. {ECO:0000305}.
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DR   EMBL; AJ302033; CAC40980.1; -; mRNA.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030504; F:inorganic diphosphate transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0030500; P:regulation of bone mineralization; ISS:UniProtKB.
DR   InterPro; IPR009887; ANKH.
DR   PANTHER; PTHR28384; PTHR28384; 1.
DR   Pfam; PF07260; ANKH; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..492
FT                   /note="Progressive ankylosis protein homolog"
FT                   /id="PRO_0000137470"
FT   TOPO_DOM        1..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..131
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..327
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        349..360
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        382..403
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        404..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        427..429
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        453..492
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  53953 MW;  753214B87D7E5F23 CRC64;
     MVKLPSLTPY WPLIRFLVPL GITNIAIDFG EQALNRGIAA VKEDAIEMLA SYGLAYSLMK
     FFTGPMSDFK NVGLVFVNSK RDRMKAVLCM VVAGIIAAVF HTLIAYSDLG YYIINKLHHV
     DESVGGKTRK AFLYLAAVPF MDAMAWTHAG ILLKHKYSFL VGCASISDVI AQVVFVAILL
     HSHLECREPL LIPILSLYIG ALVRCTTLCL GYYKNIHDKI PESSGPEIGG DATIKKMLSF
     WWPLALILAT QRISRPIVNL FVSRDLGGST AATEAVAILT ATYPVGHMPY GWLTEIRAVY
     PAFDKSNPGS KLANSSNPVS KTHIKNXTFA CMALSLTLCF VMFWTPNVSE KILVDIIGVD
     FAFAELCVIP LRIFSFFPVP VTVRAHLTGW LMTLKKTFVL APSSILRIIV LISSLIVLPY
     LGVHGATLGV GSLLAGFVGE STMVAIASLY VYRKQKKKSE TENAVEGEDS AMTDLPHNEE
     LTDIVEIKED GE