ANKK1_MOUSE
ID ANKK1_MOUSE Reviewed; 745 AA.
AC Q8BZ25;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Ankyrin repeat and protein kinase domain-containing protein 1;
DE EC=2.7.11.1;
GN Name=Ankk1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AK036872; BAC29613.1; -; mRNA.
DR CCDS; CCDS40616.1; -.
DR RefSeq; NP_766510.1; NM_172922.3.
DR AlphaFoldDB; Q8BZ25; -.
DR SMR; Q8BZ25; -.
DR STRING; 10090.ENSMUSP00000034792; -.
DR iPTMnet; Q8BZ25; -.
DR PhosphoSitePlus; Q8BZ25; -.
DR MaxQB; Q8BZ25; -.
DR PaxDb; Q8BZ25; -.
DR PRIDE; Q8BZ25; -.
DR Antibodypedia; 2098; 115 antibodies from 29 providers.
DR DNASU; 244859; -.
DR Ensembl; ENSMUST00000034792; ENSMUSP00000034792; ENSMUSG00000032257.
DR GeneID; 244859; -.
DR KEGG; mmu:244859; -.
DR UCSC; uc009pjb.1; mouse.
DR CTD; 255239; -.
DR MGI; MGI:3045301; Ankk1.
DR VEuPathDB; HostDB:ENSMUSG00000032257; -.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000162060; -.
DR HOGENOM; CLU_015188_1_0_1; -.
DR InParanoid; Q8BZ25; -.
DR OMA; SIYGVCR; -.
DR OrthoDB; 1112022at2759; -.
DR PhylomeDB; Q8BZ25; -.
DR TreeFam; TF106506; -.
DR BioGRID-ORCS; 244859; 0 hits in 76 CRISPR screens.
DR PRO; PR:Q8BZ25; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BZ25; protein.
DR Bgee; ENSMUSG00000032257; Expressed in striatum and 8 other tissues.
DR ExpressionAtlas; Q8BZ25; baseline and differential.
DR GO; GO:0042995; C:cell projection; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0010564; P:regulation of cell cycle process; IDA:MGI.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 11.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Repeat; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..745
FT /note="Ankyrin repeat and protein kinase domain-containing
FT protein 1"
FT /id="PRO_0000085621"
FT DOMAIN 34..301
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 369..398
FT /note="ANK 1"
FT REPEAT 402..431
FT /note="ANK 2"
FT REPEAT 435..464
FT /note="ANK 3"
FT REPEAT 468..497
FT /note="ANK 4"
FT REPEAT 501..530
FT /note="ANK 5"
FT REPEAT 534..563
FT /note="ANK 6"
FT REPEAT 567..596
FT /note="ANK 7"
FT REPEAT 600..629
FT /note="ANK 8"
FT REPEAT 633..662
FT /note="ANK 9"
FT REPEAT 666..695
FT /note="ANK 10"
FT REPEAT 699..728
FT /note="ANK 11"
FT ACT_SITE 157
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 40..48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 63
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 745 AA; 82480 MW; DDD391ECD19EB84D CRC64;
MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ ARHKRWRTQY
AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG VCKQPLGIVM EFMASGSLEK
TLPTHSLCWP LKLRIIHETS LAMNFLHSIK PPLLHLDLKP GNILLDNNMH VKISDFGLSK
WMEQSTQKQY IERSALRGTL SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG
LNMMTIIIRV AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML
LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK WILQLSDSKS
LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT ASGYTPLLIA TQDQQPDLCA
LLLAHGADTN LADEDGWAPL HFAAQNGDDH TARLLLDHGA LVNAREHEGW TPLHLAAQNN
FENVARLLVS RQADLSPHEA EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH
LAVERGKVRA IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ
GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM LALLQCGANP
NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG WTPAHLAALK GNTAILKVLV
KAAAQVDVKG GVSCTPLQLA IHSPK
