ID   ANKR1_BOVIN             Reviewed;         319 AA.
AC   Q3ZBX7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
GN   Name=ANKRD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in endothelial cell activation.
CC       May act as a nuclear transcription factor that negatively regulates the
CC       expression of cardiac genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TTN/titin and YBX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC103045; AAI03046.1; -; mRNA.
DR   RefSeq; NP_001029550.1; NM_001034378.2.
DR   AlphaFoldDB; Q3ZBX7; -.
DR   SMR; Q3ZBX7; -.
DR   STRING; 9913.ENSBTAP00000015584; -.
DR   PaxDb; Q3ZBX7; -.
DR   Ensembl; ENSBTAT00000015584; ENSBTAP00000015584; ENSBTAG00000011734.
DR   GeneID; 510376; -.
DR   KEGG; bta:510376; -.
DR   CTD; 27063; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011734; -.
DR   VGNC; VGNC:25908; ANKRD1.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000153956; -.
DR   HOGENOM; CLU_000134_11_1_1; -.
DR   InParanoid; Q3ZBX7; -.
DR   OMA; HSTALHW; -.
DR   OrthoDB; 1514637at2759; -.
DR   TreeFam; TF331650; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000011734; Expressed in cardiac ventricle and 79 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR   GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0031432; F:titin binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Ensembl.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..319
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240478"
FT   REPEAT          152..181
FT                   /note="ANK 1"
FT   REPEAT          185..214
FT                   /note="ANK 2"
FT   REPEAT          218..247
FT                   /note="ANK 3"
FT   REPEAT          251..280
FT                   /note="ANK 4"
FT   REPEAT          284..315
FT                   /note="ANK 5"
FT   COILED          61..89
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36165 MW;  17B662EB6471F2BB CRC64;
     MMVLKVEELV TGKKKGNGDA GEFLPEDFRD GEYEAAVTLE KQEDLKTLPV HFVSLGEQQW
     KTEKQREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYK KTKVPVVKEP EPEIVTEPVD
     VPMFLKAALE NKLPVIEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLIEAGAQIE
     FRDMLESTAI HWASRGGSLD VLKLLLNKGA KISARDKLLS TPLHVAVRTG HYECAEHLIA
     CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LITYGADLNV KNCAGKTPMD LVLHWQNGTK
     AIFDSLKENS YKASRIAAF