ID   ANKR1_CHICK             Reviewed;         319 AA.
AC   Q7ZT11;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
DE   AltName: Full=Cardiac ankyrin repeat protein;
GN   Name=ANKRD1; Synonyms=CARP;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RA   Oda A., Uyeda A., Fujimori K., Kawasaki T., Taguchi T.;
RT   "Chicken cardiac ankyrin repeat protein mRNA.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a nuclear transcription factor that negatively
CC       regulates the expression of cardiac genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AB082934; BAC66488.1; -; mRNA.
DR   EMBL; AB082935; BAC66489.1; -; mRNA.
DR   RefSeq; NP_989736.1; NM_204405.1.
DR   AlphaFoldDB; Q7ZT11; -.
DR   SMR; Q7ZT11; -.
DR   STRING; 9031.ENSGALP00000010477; -.
DR   PaxDb; Q7ZT11; -.
DR   GeneID; 378926; -.
DR   KEGG; gga:378926; -.
DR   CTD; 27063; -.
DR   VEuPathDB; HostDB:geneid_378926; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; Q7ZT11; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q7ZT11; -.
DR   PRO; PR:Q7ZT11; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IMP:AgBase.
DR   GO; GO:0045445; P:myoblast differentiation; IMP:AgBase.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR   GO; GO:2000288; P:positive regulation of myoblast proliferation; IMP:AgBase.
DR   GO; GO:0009791; P:post-embryonic development; IMP:AgBase.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:AgBase.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IMP:AgBase.
DR   GO; GO:0014866; P:skeletal myofibril assembly; IMP:AgBase.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..319
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240484"
FT   REPEAT          152..181
FT                   /note="ANK 1"
FT   REPEAT          185..214
FT                   /note="ANK 2"
FT   REPEAT          218..247
FT                   /note="ANK 3"
FT   REPEAT          251..280
FT                   /note="ANK 4"
FT   REPEAT          284..315
FT                   /note="ANK 5"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  36273 MW;  7DE4B6B2AF6BB696 CRC64;
     MMTMKVEELV TGKKTDDKES GSFLPEDFKT GEYEAAVKLE KQDDLRTASD HLSTQVDMAH
     GKEKKREAEL KKKKLQERSK LESLEDLEKI IQLKKKKKCR KVKAPLLKEP EPEVITGPVD
     IAMFFRAALE NKLPVIEKYL SDKGDPNVCN EYKRTALHRA CSEGHLEVVK KLVEAGALLE
     LKDMLESTAL HWACRGGNLE IVKFLLDKGI NRNARDKLRS TPLHVAVRTG QHDCAEHLIA
     CEADLNAKDR EGDTPMHDAV RLNRYKMVRL LILYGADLTI KNVDGKTPMD LVLQWQNGTK
     ELFNNLKNNS YKSAHLNKF