ID   ANKR1_PIG               Reviewed;         319 AA.
AC   Q865U8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
DE   AltName: Full=Cardiac ankyrin repeat protein;
GN   Name=ANKRD1; Synonyms=CARP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY DOXORUBICIN, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Heart;
RX   PubMed=14984723; DOI=10.1016/j.ejheart.2003.11.004;
RA   Torrado M., Lopez E., Centeno A., Castro-Beiras A., Mikhailov A.T.;
RT   "Left-right asymmetric ventricular expression of CARP in the piglet heart:
RT   regional response to experimental heart failure.";
RL   Eur. J. Heart Fail. 6:161-172(2004).
CC   -!- FUNCTION: May play an important role in endothelial cell activation.
CC       May act as a nuclear transcription factor that negatively regulates the
CC       expression of cardiac genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TTN/titin and YBX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in heart. In postnatal neonatal heart, it
CC       is expressed in an asymmetrical way; left ventricle favored towards
CC       right ventricle. Whether or not this could be correlated with a
CC       hypertrophic heart is still a matter of debate. Levels increase
CC       gradually from newborn to adult. {ECO:0000269|PubMed:14984723}.
CC   -!- INDUCTION: Down-regulated by doxorubicin (adriamycin), in vitro.
CC       {ECO:0000269|PubMed:14984723}.
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DR   EMBL; AY248702; AAO74642.1; -; mRNA.
DR   RefSeq; NP_999087.1; NM_213922.1.
DR   AlphaFoldDB; Q865U8; -.
DR   SMR; Q865U8; -.
DR   STRING; 9823.ENSSSCP00000011149; -.
DR   PaxDb; Q865U8; -.
DR   PRIDE; Q865U8; -.
DR   Ensembl; ENSSSCT00005005684; ENSSSCP00005003282; ENSSSCG00005003705.
DR   Ensembl; ENSSSCT00015101757; ENSSSCP00015042171; ENSSSCG00015075218.
DR   Ensembl; ENSSSCT00040020179; ENSSSCP00040008439; ENSSSCG00040014998.
DR   Ensembl; ENSSSCT00055036296; ENSSSCP00055028828; ENSSSCG00055018525.
DR   Ensembl; ENSSSCT00070041956; ENSSSCP00070035242; ENSSSCG00070021066.
DR   GeneID; 396959; -.
DR   KEGG; ssc:396959; -.
DR   CTD; 27063; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   HOGENOM; CLU_000134_11_1_1; -.
DR   InParanoid; Q865U8; -.
DR   OMA; HSTALHW; -.
DR   OrthoDB; 1514637at2759; -.
DR   TreeFam; TF331650; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 14.
DR   Genevisible; Q865U8; SS.
DR   GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
DR   GO; GO:0003779; F:actin binding; IPI:BHF-UCL.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0031432; F:titin binding; IPI:BHF-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..319
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240481"
FT   REPEAT          152..181
FT                   /note="ANK 1"
FT   REPEAT          185..214
FT                   /note="ANK 2"
FT   REPEAT          218..247
FT                   /note="ANK 3"
FT   REPEAT          251..280
FT                   /note="ANK 4"
FT   REPEAT          284..315
FT                   /note="ANK 5"
FT   COILED          63..89
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36126 MW;  333706C79767B1A8 CRC64;
     MMVLKVEELV TGKKNGGGDA GEFLPEDFRD GEYEAAVTLE KQEDLKTLPA HFVSLGEQQW
     KIEKEREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVVKEP EPEVITEPVD
     VPRFLKAALE NKLPVVEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLIEAGAQIE
     FRDMLESTAI HWASRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA
     CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LITYGADLNV KNCAGKTPMD LVLNWQNGTK
     AIFDSLKENS YKASRIATF