ID   ANKR1_RABIT             Reviewed;         319 AA.
AC   Q9TU71;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
DE   AltName: Full=Cardiac adriamycin-responsive protein;
DE   AltName: Full=Cardiac ankyrin repeat protein;
GN   Name=ANKRD1; Synonyms=CARP;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION BY DOXORUBICIN.
RC   TISSUE=Heart;
RX   PubMed=10542334; DOI=10.1016/s0167-4781(99)00171-2;
RA   Aihara Y., Kurabayashi M., Arai M., Kedes L., Nagai R.;
RT   "Molecular cloning of rabbit CARP cDNA and its regulated expression in
RT   adriamycin-cardiomyopathy.";
RL   Biochim. Biophys. Acta 1447:318-324(1999).
CC   -!- FUNCTION: May play an important role in endothelial cell activation.
CC       May act as a nuclear transcription factor that negatively regulates the
CC       expression of cardiac genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TTN/titin and YBX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Down-regulated by doxorubicin (adriamycin), in vitro.
CC       {ECO:0000269|PubMed:10542334}.
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DR   EMBL; AF131883; AAF13817.1; -; mRNA.
DR   RefSeq; NP_001075523.1; NM_001082054.1.
DR   AlphaFoldDB; Q9TU71; -.
DR   SMR; Q9TU71; -.
DR   STRING; 9986.ENSOCUP00000005966; -.
DR   PRIDE; Q9TU71; -.
DR   GeneID; 100008719; -.
DR   KEGG; ocu:100008719; -.
DR   CTD; 27063; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; Q9TU71; -.
DR   OrthoDB; 1514637at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..319
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240482"
FT   REPEAT          152..181
FT                   /note="ANK 1"
FT   REPEAT          185..214
FT                   /note="ANK 2"
FT   REPEAT          218..247
FT                   /note="ANK 3"
FT   REPEAT          251..280
FT                   /note="ANK 4"
FT   REPEAT          284..315
FT                   /note="ANK 5"
FT   COILED          63..89
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36246 MW;  C7EF87A02936FED3 CRC64;
     MMVLKVEELV TGKKSSNGET GEFLPDDFRD GQYEAAVTSE KQEDLKTLPA HHVSLAEQQW
     EREKQLEAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVAKEP EPEIITEPVD
     VPRFLKAALE NKLAVVEKFL SDQNNPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE
     FRDMLESTAI HWACRGGNLE VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA
     CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LIMYGADLTI KNSAGKTPMD LVLNWQNGTK
     AIFDSLKENS YKTSRIATF