ID   3SEC_DENPO              Reviewed;          61 AA.
AC   P25681;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Acetylcholinesterase toxin C;
DE   AltName: Full=Fasciculin;
OS   Dendroaspis polylepis polylepis (Black mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8620;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TOXIC DOSE.
RC   TISSUE=Venom;
RA   Joubert F.J., Taljaard N.;
RT   "The complete primary structure of toxin C from Dendroaspis polylepis
RT   polylepis (black mamba) venom.";
RL   S. Afr. J. Chem. 31:107-110(1978).
CC   -!- FUNCTION: Inhibits acetylcholinesterase.
CC       {ECO:0000250|UniProtKB:P0C1Z0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 2.1 +/- 0.2 mg/kg by intravenous injection.
CC       {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Acn-esterase inhibitor sub-subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P25681; -.
DR   SMR; P25681; -.
DR   PRIDE; P25681; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..61
FT                   /note="Acetylcholinesterase toxin C"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000093656"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        17..39
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        41..52
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        53..59
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ   SEQUENCE   61 AA;  6817 MW;  66625EF767341F3A CRC64;
     TICYSHTTTS RAILKDCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDYLEV KCCTSPDKCN
     Y