ID   ANKR1_XENLA             Reviewed;         318 AA.
AC   Q4KL97;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
GN   Name=ankrd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a nuclear transcription factor that negatively
CC       regulates the expression of cardiac genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC099339; AAH99339.1; -; mRNA.
DR   RefSeq; NP_001089636.1; NM_001096167.1.
DR   AlphaFoldDB; Q4KL97; -.
DR   SMR; Q4KL97; -.
DR   DNASU; 734696; -.
DR   GeneID; 734696; -.
DR   KEGG; xla:734696; -.
DR   CTD; 734696; -.
DR   Xenbase; XB-GENE-974657; ankrd1.L.
DR   OrthoDB; 1514637at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 734696; Expressed in muscle tissue and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..318
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240485"
FT   REPEAT          151..180
FT                   /note="ANK 1"
FT   REPEAT          184..213
FT                   /note="ANK 2"
FT   REPEAT          217..246
FT                   /note="ANK 3"
FT   REPEAT          250..279
FT                   /note="ANK 4"
FT   REPEAT          283..314
FT                   /note="ANK 5"
FT   COILED          37..77
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  36073 MW;  7F57A1AEDFA99E41 CRC64;
     MLLKMEEMVI EKKNEMKQTG DFVSGVSKNG EYETAVALEK QEDLKTTSKS LIELEEEKQS
     KEKQLKSELL KKKLEERPKL DNLEDLQTII NLKKRKRVKK VKVPVVKEPE PEETIGDVDQ
     MTFFKAALDN KMSIIEKYLA DGGDPNTCDE YKRTALHRAC SEGHTAIVEK LIEAGANIEF
     KDMLESTALH WTCRGGSVET LKLLLNKGAA INARDKLLST PLHVAVRTGY YECGEHLIAC
     EADLNAKDRE GDTPMHDGVR LNRYKMIRLL ILYGVNLNIK NCAGKTPMEL VMQWQNGAKE
     IFNGLQNKSY KNSHISKF