ID   ANKR1_XENTR             Reviewed;         318 AA.
AC   Q5BKI6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Ankyrin repeat domain-containing protein 1;
GN   Name=ankrd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a nuclear transcription factor that negatively
CC       regulates the expression of cardiac genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC091060; AAH91060.1; -; mRNA.
DR   RefSeq; NP_001025607.1; NM_001030436.1.
DR   AlphaFoldDB; Q5BKI6; -.
DR   SMR; Q5BKI6; -.
DR   STRING; 8364.ENSXETP00000047089; -.
DR   PaxDb; Q5BKI6; -.
DR   DNASU; 594995; -.
DR   Ensembl; ENSXETT00000047089; ENSXETP00000047089; ENSXETG00000021783.
DR   GeneID; 594995; -.
DR   KEGG; xtr:594995; -.
DR   CTD; 27063; -.
DR   Xenbase; XB-GENE-974650; ankrd1.
DR   eggNOG; KOG0504; Eukaryota.
DR   HOGENOM; CLU_000134_11_1_1; -.
DR   InParanoid; Q5BKI6; -.
DR   OMA; HSTALHW; -.
DR   OrthoDB; 1514637at2759; -.
DR   PhylomeDB; Q5BKI6; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021783; Expressed in skeletal muscle tissue and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..318
FT                   /note="Ankyrin repeat domain-containing protein 1"
FT                   /id="PRO_0000240486"
FT   REPEAT          118..147
FT                   /note="ANK 1"
FT   REPEAT          151..180
FT                   /note="ANK 2"
FT   REPEAT          184..213
FT                   /note="ANK 3"
FT   REPEAT          217..246
FT                   /note="ANK 4"
FT   REPEAT          250..279
FT                   /note="ANK 5"
FT   REPEAT          283..314
FT                   /note="ANK 6"
FT   COILED          37..77
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  36231 MW;  C8878EEFC2C76072 CRC64;
     MLLKMEEMVP EKKNEMKKTS NFVAGVSKNG EYETAVALEK QEDLKTTSKS LIELEEEKQI
     KEKQLKSELL KKKLEERPKL DNLEDLQTII NLKKRKRVKK VHVPVVKEPE PEEIIENVDQ
     TTFFKAALDN KMPVIEKYLA DGGDPNTCDE YKRTALHRAC SEGHTDMVEK LIEAGANIEF
     KDMLESTALH WTCRGGSVET LKLLLNKGAA INARDKLLST PLHVAVRTGH YECAEHLIAC
     EADLHARDRE GDTPMHDGVR LNRYKMMRLL ILYGVDLNIK NSAGKTPMEL VMQWQNGAKE
     IFNGLQSKSY KNSHISKF