ANKR7_HUMAN
ID ANKR7_HUMAN Reviewed; 254 AA.
AC Q92527; B4DYF5; Q96QN1; Q9UDM3;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Ankyrin repeat domain-containing protein 7;
DE AltName: Full=Testis-specific protein TSA806;
GN Name=ANKRD7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-254 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 104-191 (ISOFORMS 1/2).
RC TISSUE=Testis;
RX PubMed=8812458; DOI=10.1006/geno.1996.0467;
RA Ozaki K., Kuroki T., Hayashi S., Nakamura Y.;
RT "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a
RT differential mRNA display method.";
RL Genomics 36:316-319(1996).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q92527-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q92527-2; Sequence=VSP_037160;
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32799.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK302407; BAG63717.1; -; mRNA.
DR EMBL; AC004029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC007874; AAF19231.1; -; Genomic_DNA.
DR EMBL; BC032799; AAH32799.1; ALT_INIT; mRNA.
DR EMBL; BC007020; AAH07020.2; -; mRNA.
DR EMBL; D78334; BAA11348.1; -; mRNA.
DR CCDS; CCDS43638.1; -. [Q92527-1]
DR RefSeq; NP_062618.2; NM_019644.3. [Q92527-1]
DR AlphaFoldDB; Q92527; -.
DR SMR; Q92527; -.
DR BioGRID; 121138; 1.
DR IntAct; Q92527; 3.
DR MINT; Q92527; -.
DR STRING; 9606.ENSP00000349612; -.
DR iPTMnet; Q92527; -.
DR PhosphoSitePlus; Q92527; -.
DR BioMuta; ANKRD7; -.
DR DMDM; 229462988; -.
DR MassIVE; Q92527; -.
DR PaxDb; Q92527; -.
DR PeptideAtlas; Q92527; -.
DR PRIDE; Q92527; -.
DR ProteomicsDB; 75287; -. [Q92527-1]
DR ProteomicsDB; 75288; -. [Q92527-2]
DR Antibodypedia; 31679; 88 antibodies from 22 providers.
DR DNASU; 56311; -.
DR Ensembl; ENST00000265224.9; ENSP00000265224.4; ENSG00000106013.15. [Q92527-1]
DR GeneID; 56311; -.
DR KEGG; hsa:56311; -.
DR MANE-Select; ENST00000265224.9; ENSP00000265224.4; NM_019644.4; NP_062618.2.
DR UCSC; uc003vji.4; human. [Q92527-1]
DR CTD; 56311; -.
DR DisGeNET; 56311; -.
DR GeneCards; ANKRD7; -.
DR HGNC; HGNC:18588; ANKRD7.
DR HPA; ENSG00000106013; Tissue enriched (testis).
DR MIM; 610731; gene.
DR neXtProt; NX_Q92527; -.
DR OpenTargets; ENSG00000106013; -.
DR PharmGKB; PA38591; -.
DR VEuPathDB; HostDB:ENSG00000106013; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000164704; -.
DR HOGENOM; CLU_000134_9_1_1; -.
DR InParanoid; Q92527; -.
DR OMA; LSCQDIC; -.
DR PhylomeDB; Q92527; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; Q92527; -.
DR SignaLink; Q92527; -.
DR BioGRID-ORCS; 56311; 11 hits in 1066 CRISPR screens.
DR ChiTaRS; ANKRD7; human.
DR GenomeRNAi; 56311; -.
DR Pharos; Q92527; Tdark.
DR PRO; PR:Q92527; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q92527; protein.
DR Bgee; ENSG00000106013; Expressed in left testis and 102 other tissues.
DR ExpressionAtlas; Q92527; baseline and differential.
DR Genevisible; Q92527; HS.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..254
FT /note="Ankyrin repeat domain-containing protein 7"
FT /id="PRO_0000066902"
FT REPEAT 58..87
FT /note="ANK 1"
FT REPEAT 91..120
FT /note="ANK 2"
FT REPEAT 124..153
FT /note="ANK 3"
FT REPEAT 157..186
FT /note="ANK 4"
FT REPEAT 190..219
FT /note="ANK 5"
FT VAR_SEQ 59
FT /note="Y -> YSVVQSSRWLLSYTTPLNDFI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_037160"
FT CONFLICT 104..108
FT /note="NEDCA -> MRIVP (in Ref. 4; BAA11348)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 254 AA; 29029 MW; F4DC8875BD348C39 CRC64;
MNKLFSFWKR KNETRSQGYN LREKDLKKLH RAASVGDLKK LKEYLQIKKY DVNMQDKKYR
TPLHLACANG HTDVVLFLIE QQCKINVRDS ENKSPLIKAV QCQNEDCATI LLNFGADPDL
RDIRYNTVLH YAVCGQSLSL VEKLLEYEAD LEAKNKDGYT PLLVAVINNN PKMVKFLLEK
GADVNASDNY QRTALILAVS GEPPCLVKLL LQQGVELCYE GIVDSQLRNM FISMVLLHRY
PQFTASHGKK KHAK
