ID   3SHD_NEUCR              Reviewed;         359 AA.
AC   P07046; Q7RVA2;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=3-dehydroshikimate dehydratase;
DE            Short=DHS dehydratase;
DE            Short=DHSase;
DE            EC=4.2.1.-;
GN   Name=qa-4; ORFNames=NCU06024;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=2525625; DOI=10.1016/0022-2836(89)90438-5;
RA   Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J.,
RA   Case M.E., Giles N.H.;
RT   "DNA sequence, organization and regulation of the qa gene cluster of
RT   Neurospora crassa.";
RL   J. Mol. Biol. 207:15-34(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6241580; DOI=10.1016/0378-1119(84)90003-9;
RA   Rutledge B.J.;
RT   "Molecular characterization of the qa-4 gene of Neurospora crassa.";
RL   Gene 32:275-287(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Converts dehydroshikimate to protocatechuate.
CC   -!- PATHWAY: Aromatic compound metabolism; 3,4-dihydroxybenzoate
CC       biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 2/2.
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DR   EMBL; X14603; CAA32750.1; -; Genomic_DNA.
DR   EMBL; M10139; AAA33613.1; -; Genomic_DNA.
DR   EMBL; CM002242; EAA30378.1; -; Genomic_DNA.
DR   PIR; A22421; A22421.
DR   RefSeq; XP_959614.1; XM_954521.2.
DR   AlphaFoldDB; P07046; -.
DR   STRING; 5141.EFNCRP00000005479; -.
DR   EnsemblFungi; EAA30378; EAA30378; NCU06024.
DR   GeneID; 3875773; -.
DR   KEGG; ncr:NCU06024; -.
DR   VEuPathDB; FungiDB:NCU06024; -.
DR   HOGENOM; CLU_035063_0_0_1; -.
DR   InParanoid; P07046; -.
DR   OMA; HPFYNAE; -.
DR   BioCyc; MetaCyc:MON-15329; -.
DR   UniPathway; UPA00088; UER00179.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046279; P:3,4-dihydroxybenzoate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019630; P:quinate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   4: Predicted;
KW   Lyase; Quinate metabolism; Reference proteome.
FT   CHAIN           1..359
FT                   /note="3-dehydroshikimate dehydratase"
FT                   /id="PRO_0000064378"
SQ   SEQUENCE   359 AA;  40493 MW;  AF3111E617320F12 CRC64;
     MPSKLAISSM SLGRCFAGHS LDSKLDAAQR YGYLGIELFY EDLVDVAEHL SNERPSPEGP
     FVEAQIAAAR HILQMCQARG LEVVCLQPFM HYDGLNDRAE HERRLEKLAL WIELAHELHT
     DIIQIPANFL PANQVSDNLD LIVSDLCKVA DIGAQALPPI RFAYESLCWS TRVDLWERCW
     DIVQRVDRPN FGICLDTFNI LGRIYADPTS PSGRTPNAKE AVRKSIANLV SRVDVSKVFY
     VQVVDAERLS KPLLPGHPYY NPEQPARMSW SRNCRLFYGE TEYGAYLPVK EVARALFHGI
     GFEGWVSLEL FNRRMSEEGP EVPEELAMRG AISWAKLVQD LRIPVEGPLV TMPRVSASL