ANKY2_HUMAN
ID ANKY2_HUMAN Reviewed; 441 AA.
AC Q8IV38; A4D124; Q659G1; Q96BL3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Ankyrin repeat and MYND domain-containing protein 2;
GN Name=ANKMY2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in the trafficking of signaling proteins to
CC the cilia. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the retinal-specific guanylyl cyclase GC1.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IV38; Q9BSI4: TINF2; NbExp=2; IntAct=EBI-9393876, EBI-717399;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
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DR EMBL; AL050390; CAH56419.1; -; mRNA.
DR EMBL; CH236948; EAL24286.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW93672.1; -; Genomic_DNA.
DR EMBL; BC015453; AAH15453.1; -; mRNA.
DR EMBL; BC035353; AAH35353.1; -; mRNA.
DR CCDS; CCDS5361.1; -.
DR RefSeq; NP_064715.1; NM_020319.2.
DR AlphaFoldDB; Q8IV38; -.
DR SMR; Q8IV38; -.
DR BioGRID; 121333; 55.
DR IntAct; Q8IV38; 21.
DR STRING; 9606.ENSP00000303570; -.
DR iPTMnet; Q8IV38; -.
DR PhosphoSitePlus; Q8IV38; -.
DR BioMuta; ANKMY2; -.
DR DMDM; 74750650; -.
DR EPD; Q8IV38; -.
DR jPOST; Q8IV38; -.
DR MassIVE; Q8IV38; -.
DR MaxQB; Q8IV38; -.
DR PaxDb; Q8IV38; -.
DR PeptideAtlas; Q8IV38; -.
DR PRIDE; Q8IV38; -.
DR ProteomicsDB; 70655; -.
DR Antibodypedia; 43960; 193 antibodies from 19 providers.
DR DNASU; 57037; -.
DR Ensembl; ENST00000306999.7; ENSP00000303570.2; ENSG00000106524.9.
DR GeneID; 57037; -.
DR KEGG; hsa:57037; -.
DR MANE-Select; ENST00000306999.7; ENSP00000303570.2; NM_020319.3; NP_064715.1.
DR UCSC; uc003sti.3; human.
DR CTD; 57037; -.
DR GeneCards; ANKMY2; -.
DR HGNC; HGNC:25370; ANKMY2.
DR HPA; ENSG00000106524; Low tissue specificity.
DR neXtProt; NX_Q8IV38; -.
DR OpenTargets; ENSG00000106524; -.
DR PharmGKB; PA134893861; -.
DR VEuPathDB; HostDB:ENSG00000106524; -.
DR eggNOG; KOG1710; Eukaryota.
DR GeneTree; ENSGT00390000016820; -.
DR InParanoid; Q8IV38; -.
DR OMA; AFKYHYL; -.
DR OrthoDB; 1413951at2759; -.
DR PhylomeDB; Q8IV38; -.
DR TreeFam; TF351374; -.
DR PathwayCommons; Q8IV38; -.
DR SignaLink; Q8IV38; -.
DR BioGRID-ORCS; 57037; 53 hits in 1075 CRISPR screens.
DR ChiTaRS; ANKMY2; human.
DR GenomeRNAi; 57037; -.
DR Pharos; Q8IV38; Tdark.
DR PRO; PR:Q8IV38; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IV38; protein.
DR Bgee; ENSG00000106524; Expressed in middle temporal gyrus and 207 other tissues.
DR ExpressionAtlas; Q8IV38; baseline and differential.
DR Genevisible; Q8IV38; HS.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR002893; Znf_MYND.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Cell projection; Cilium; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..441
FT /note="Ankyrin repeat and MYND domain-containing protein 2"
FT /id="PRO_0000247166"
FT REPEAT 45..74
FT /note="ANK 1"
FT REPEAT 79..108
FT /note="ANK 2"
FT REPEAT 159..188
FT /note="ANK 3"
FT ZN_FING 320..357
FT /note="MYND-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT REGION 374..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 320
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 323
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 332
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 335
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 341
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 345
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 353
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 357
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT CONFLICT 273
FT /note="K -> KISLLMAFQCIKKRSLEKVSEK (in Ref. 1; CAH56419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 49299 MW; E9A5E1B9ABCBA4A6 CRC64;
MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLSSKNVRVN CLDENGMTPL MHAAYKGKLD
MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA
AFVGQHDCVT IINNFFPRER LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM
LVNENPLLTE EAALNKCYRV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDGE
NKLDTLIKSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA
FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FTHKKICKNL
KDIYEKQQLE AAKEKRQEEN HGKLDVNSNC VNEEQPEAEV GISQKDSNPE DSGEGKKESL
ESEAELEGLQ DAPAGPQVSE E
