ID   HEMGN_BOVIN             Reviewed;         447 AA.
AC   Q32L62;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Hemogen;
DE   AltName: Full=Hemopoietic gene protein;
GN   Name=HEMGN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the proliferation and differentiation of
CC       hematopoietic cells. Overexpression block the TPA-induced
CC       megakaryocytic differentiation in the K562 cell model. May also prevent
CC       cell apoptosis through the activation of the nuclear factor-kappa B
CC       (NF-kB) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC109747; AAI09748.1; -; mRNA.
DR   RefSeq; NP_001070523.1; NM_001077055.2.
DR   AlphaFoldDB; Q32L62; -.
DR   STRING; 9913.ENSBTAP00000043053; -.
DR   PaxDb; Q32L62; -.
DR   PRIDE; Q32L62; -.
DR   GeneID; 767995; -.
DR   KEGG; bta:767995; -.
DR   CTD; 55363; -.
DR   eggNOG; ENOG502SBFR; Eukaryota.
DR   InParanoid; Q32L62; -.
DR   OrthoDB; 801077at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0045667; P:regulation of osteoblast differentiation; IBA:GO_Central.
DR   InterPro; IPR033272; Hemogen.
DR   PANTHER; PTHR15993; PTHR15993; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..447
FT                   /note="Hemogen"
FT                   /id="PRO_0000245360"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          7..86
FT                   /note="Necessary for nuclear localization"
FT                   /evidence="ECO:0000250"
FT   REGION          137..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AZ54"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BXL5"
FT   MOD_RES         200
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERZ0"
FT   MOD_RES         217
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERZ0"
SQ   SEQUENCE   447 AA;  51136 MW;  707C2AB766CC3C55 CRC64;
     MDLGKDQSLS KLHQTPDHHQ EESHVPEVIG TWSLRNREQL RKRKAEAQEK QTSQWQYREK
     KHKRQRTGKR SERGRKRQQN TEMKVELPSQ LEKEMMEKAP APGEKEIEPP GSVTEVLLPA
     VSPQRVAPAK HLSEVGQESV TLQENSSEYQ ATAVQNQPSE ICQDMAESED LSPKMCQEIA
     IFQDQPFKMF RNMAQPEDVS PKTCQEDIAA KVLSSKTSED TTDLEECSLE AHPKPDMPKA
     STLETYQKRP EPEEPDSETG QGIVETESFV SNTQQEMAVP KELATEIHQE TVEPEHFSHK
     IYREIAMSKD PSHKTTQETS VPDKYPPEMY QETPGSEEYS LEIYQETTGP EAYAPEIYQE
     TPGPEDLSTK TYKDKDVPKE CFPKLYQEIG GPQDQDSKAH QEDAKDVYTF PQEMKENPKA
     EEPEIIEIPN VPQESNPEND IYSYVLF