ID   HEMH1_ORYSJ             Reviewed;         482 AA.
AC   Q69TB1;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Ferrochelatase-1, chloroplastic;
DE            EC=4.99.1.1;
DE   AltName: Full=Ferrochelatase I;
DE   AltName: Full=Heme synthase 1;
DE   AltName: Full=Protoheme ferro-lyase 1;
DE   Flags: Precursor;
GN   OrderedLocusNames=Os09g0297000, LOC_Os09g12560; ORFNames=P0592C05.24;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + heme b = Fe(2+) + protoporphyrin IX;
CC         Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.99.1.1;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ferrochelatase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP004756; BAD33213.1; -; Genomic_DNA.
DR   EMBL; AP008215; BAF24717.1; -; Genomic_DNA.
DR   EMBL; AP014965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK068174; BAG90790.1; -; mRNA.
DR   RefSeq; XP_015611979.1; XM_015756493.1.
DR   AlphaFoldDB; Q69TB1; -.
DR   SMR; Q69TB1; -.
DR   STRING; 4530.OS09T0297000-01; -.
DR   PaxDb; Q69TB1; -.
DR   PRIDE; Q69TB1; -.
DR   GeneID; 4346651; -.
DR   KEGG; osa:4346651; -.
DR   eggNOG; KOG1321; Eukaryota.
DR   HOGENOM; CLU_018884_4_2_1; -.
DR   InParanoid; Q69TB1; -.
DR   OrthoDB; 1003638at2759; -.
DR   BRENDA; 4.99.1.1; 8948.
DR   UniPathway; UPA00252; UER00325.
DR   Proteomes; UP000000763; Chromosome 9.
DR   Proteomes; UP000059680; Chromosome 9.
DR   Genevisible; Q69TB1; OS.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004325; F:ferrochelatase activity; IBA:GO_Central.
DR   GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR   CDD; cd00419; Ferrochelatase_C; 1.
DR   CDD; cd03411; Ferrochelatase_N; 1.
DR   HAMAP; MF_00323; Ferrochelatase; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   InterPro; IPR033644; Ferrochelatase_C.
DR   InterPro; IPR033659; Ferrochelatase_N.
DR   PANTHER; PTHR11108; PTHR11108; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Heme biosynthesis; Iron; Lyase; Plastid;
KW   Porphyrin biosynthesis; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..482
FT                   /note="Ferrochelatase-1, chloroplastic"
FT                   /id="PRO_0000376075"
SQ   SEQUENCE   482 AA;  53252 MW;  63F53C2B81373661 CRC64;
     MECVRSGSGV LDPRCSPRFL GKKGGSLTSC GKATSTNLAI CTKHEQNLHG NVKPSQLAAS
     GSSYSVHRSP VLKQRQNLSA RSTSADVYTT FDENVRAVSS HAAEEKVGVL LLNLGGPETL
     DDVQPFLFNL FADPDIIRLP RLFRFLQRPL AKLISTFRAP KSKEGYASIG GGSPLRKITD
     EQANALKVAL KKKNLNANIY VGMRYWYPFT EEAIDQIKKD KITKLVVLPL YPQYSISTSG
     SSIRVLQNIV KEDSYFAGLP ISIIESWYQR DGYVKSMADL IEKELSIFSN PEEVMIFFSA
     HGVPLTYVTD AGDPYRDQME DCIALIMGEL KSRGILNSHT LAYQSRVGPV QWLKPYTDEV
     LVELGQQGVK SLLAVPVSFV SEHIETLEEI DMEYKELALE SGIENWGRVP ALGCTSSFIS
     DLADAVVEAL PSASALVTKK VDESDSDMDL MHYLSKMFFG SILAFVLLLS PRLISAFRNT
     LL