ANM16_ARATH
ID ANM16_ARATH Reviewed; 724 AA.
AC Q944R7; O23501;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein arginine N-methyltransferase 1.6;
DE Short=AtPRMT16;
DE Short=AtPRMT7;
DE EC=2.1.1.-;
GN Name=PRMT16; Synonyms=PRMT7; OrderedLocusNames=At4g16570;
GN ORFNames=dl4310w, FCAALL.195;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17005254; DOI=10.1016/j.pharmthera.2006.06.007;
RA Krause C.D., Yang Z.-H., Kim Y.-S., Lee J.-H., Cook J.R., Pestka S.;
RT "Protein arginine methyltransferases: evolution and assessment of their
RT pharmacological and therapeutic potential.";
RL Pharmacol. Ther. 113:50-87(2007).
CC -!- FUNCTION: Arginine methyltransferase that can both catalyze the
CC formation of omega-N monomethylarginine (MMA) and symmetrical
CC dimethylarginine (sDMA). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Protein arginine N-methyltransferase family. PRMT7
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01015}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL11573.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAN18172.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB10433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78699.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z97341; CAB10433.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161544; CAB78699.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83772.1; -; Genomic_DNA.
DR EMBL; AF424579; AAL11573.1; ALT_FRAME; mRNA.
DR EMBL; BT000603; AAN18172.1; ALT_FRAME; mRNA.
DR PIR; G71432; G71432.
DR RefSeq; NP_567508.1; NM_117758.3.
DR AlphaFoldDB; Q944R7; -.
DR SMR; Q944R7; -.
DR STRING; 3702.AT4G16570.1; -.
DR iPTMnet; Q944R7; -.
DR PaxDb; Q944R7; -.
DR PRIDE; Q944R7; -.
DR ProteomicsDB; 244433; -.
DR EnsemblPlants; AT4G16570.1; AT4G16570.1; AT4G16570.
DR GeneID; 827358; -.
DR Gramene; AT4G16570.1; AT4G16570.1; AT4G16570.
DR KEGG; ath:AT4G16570; -.
DR Araport; AT4G16570; -.
DR TAIR; locus:2130824; AT4G16570.
DR eggNOG; KOG1501; Eukaryota.
DR HOGENOM; CLU_015180_1_0_1; -.
DR InParanoid; Q944R7; -.
DR OMA; LPMANCA; -.
DR OrthoDB; 408622at2759; -.
DR PhylomeDB; Q944R7; -.
DR PRO; PR:Q944R7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q944R7; baseline and differential.
DR Genevisible; Q944R7; AT.
DR GO; GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IBA:GO_Central.
DR GO; GO:0018216; P:peptidyl-arginine methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; -; 2.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR014644; MeTrfase_PRMT7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006; PTHR11006; 1.
DR PIRSF; PIRSF036946; Arg_N-mtase; 1.
DR SUPFAM; SSF53335; SSF53335; 2.
DR PROSITE; PS51678; SAM_MT_PRMT; 2.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..724
FT /note="Protein arginine N-methyltransferase 1.6"
FT /id="PRO_0000294001"
FT DOMAIN 61..388
FT /note="SAM-dependent MTase PRMT-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT DOMAIN 395..721
FT /note="SAM-dependent MTase PRMT-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT ACT_SITE 183
FT /evidence="ECO:0000250"
FT ACT_SITE 192
FT /evidence="ECO:0000250"
FT CONFLICT 634
FT /note="P -> S (in Ref. 4; AAN18172/AAL11573)"
FT /evidence="ECO:0000305"
FT CONFLICT 660
FT /note="M -> V (in Ref. 4; AAN18172/AAL11573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 724 AA; 80870 MW; 4A26FFCA4665B5D2 CRC64;
MSPLSSLPPK TFISSFHCHS VTRLRRSVTA RTMSSQSSQR VFQLRQDPLT GNSEWIVIED
NDQPGTSTDG LLATTSYLDM LNDSRRNIAY RLAIEKTITE PCHVLDIGAG TGLLSMMAVR
AMRGDSKGMV TACESYLPMV KLMRKVMHKN GMTKNINLIN KRSDELKVGS EDIASRADVL
VSEILDSELL GEGLIPSLQH AHDMLLVDNP KTVPYRATTY CQLVESTFLC NLQDLRNNEA
KTSDGVRLVP PGLESLFGIK SQQYSMHVDA IEKEIKLLSE PVKIFEFDFW KRPESNGELD
VHIEAKTTGS VHAIISWWVL QLDSEGTIFY STAPRWIDSN SEIGVRDWCD HWKQCVWFTP
GTGVSISKGE KVHLHASHTC TNILYNLKKT QSLTHERTHF PLSTGDLHLT LPPERVAIYG
DSIYRQSLFE ATRKALQGKS YPQCLVIDDS LLLPLMALHI SNRSRVLSLS PGLQENAARY
FEAIADSNGF SKDRFEYFRD GKTNLAKAYP GKIDLLIGEP YYSGLENGLP WQNLRFWKDR
TLLDSVLSED AVVMPYKGVL RGCAMYLPDL WKSRCCLGSV EGFDHTLVNT TLGGCGDLPS
GKDSPCLPFF IWQCGETKIL SKEFTVMEFD FSKPITGPCS GEVQIEFIKP GVCHGIALWM
DWVMDEENST VISTGPDDKY WKQGVKLLGK PVTVRMEGPS SSIGIQASLD LSSNSELIVT
HTIS
