ID   HEMR_YEREN              Reviewed;         687 AA.
AC   P31499;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Hemin receptor;
DE   Flags: Precursor;
GN   Name=hemR;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX   PubMed=1425573; DOI=10.1002/j.1460-2075.1992.tb05535.x;
RA   Stojiljkovic I., Hantke K.;
RT   "Hemin uptake system of Yersinia enterocolitica: similarities with other
RT   TonB-dependent systems in Gram-negative bacteria.";
RL   EMBO J. 11:4359-4367(1992).
RN   [2]
RP   SEQUENCE REVISION.
RA   Stojiljkovic I.;
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   EXPRESSION.
RC   STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX   PubMed=11705959; DOI=10.1128/iai.69.12.7772-7782.2001;
RA   Jacobi C.A., Gregor S., Rakin A., Heesemann J.;
RT   "Expression analysis of the yersiniabactin receptor gene fyuA and the heme
RT   receptor hemR of Yersinia enterocolitica in vitro and in vivo using the
RT   reporter genes for green fluorescent protein and luciferase.";
RL   Infect. Immun. 69:7772-7782(2001).
CC   -!- FUNCTION: This protein is involved in the initial step of iron uptake
CC       by binding hemin, an iron chelatin siderophore that allows the bacteria
CC       to extract iron from the environment.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: Induced in absence of iron.
CC   -!- MISCELLANEOUS: Weakly expressed by yersiniae located in the liver and
CC       the intestinal lumen. Strongly expressed in yersiniae located in the
CC       peritoneal cavity. Moderately expressed in yersiniae located in the
CC       spleen. This probably reflects the availability of iron for yersiniae.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; X68147; CAA48250.1; -; Genomic_DNA.
DR   PIR; S28042; S28042.
DR   AlphaFoldDB; P31499; -.
DR   SMR; P31499; -.
DR   TCDB; 1.B.14.2.2; the outer membrane receptor (omr) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..687
FT                   /note="Hemin receptor"
FT                   /id="PRO_0000034758"
FT   REGION          319..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           44..51
FT                   /note="TonB box"
FT   MOTIF           670..687
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   687 AA;  75226 MW;  69092EF97F5DC08A CRC64;
     MPRSTSDRFR WSPLSLAIAC TLSLAVQAAD TSSTQTNSKK RIADTMVVTA TGNERSSFEA
     PMMVTVVEAD TPTSETATSA TDMLRNIPGL TVTGSGRVNG QDVTLRGYGK QGVLTLVDGI
     RQGTDTGHLN STFLDPALVK RVEIVRGPSA LLYGSGALGG VISYETVDAA DLLLPGQNSG
     YRVYSAAATG DHSFGLGASA FGRTDDVDGI LSFGTRDIGN IRQSDGFNAP NDETISNVLA
     KGTWRIDQIQ SLSANLRYYN NSALEPKNPQ TSAASSTNLM TDRSTIQRDA QLKYNIKPLD
     QEWLNATAQV YYSEVEINAR PQGTPEEGRK QTTKGGKLEN RTRLFTDSFA SHLLTYGTEA
     YKQEQTPSGA TESFPQADIR FGSGWLQDEI TLRDLPVSIL AGTRYDNYRG SSEGYADVDA
     DKWSSRGAVS VTPTDWLMLF GSYAQAFRAP TMGEMYNDSK HFSMNIMGNT LTNYWVPNPN
     LKPETNETQE YGFGLRFNDL MMAEDDLQFK ASYFDTNAKD YISTGVTMDF GFGPGGLYCK
     NCSTYSTNID RAKIWGWDAT MTYQTQWFNL GLAYNRTRGK NQNTNEWLDT INPDTVTSTL
     DVPVANSGFA VGWIGTFADR SSRVSSSGTP QAGYGVNDFY VSYKGQEQFK GMTTTVVLGN
     AFDKGYYGPQ GVPQDGRNAK FFVSYQW