HEMTL_NAEFO
ID HEMTL_NAEFO Reviewed; 119 AA.
AC Q9NH76;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Hemerythrin-like protein;
DE AltName: Full=ARG-1;
GN Name=nfa1;
OS Naegleria fowleri (Brain eating amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5763;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 30215 / Nf 69;
RX PubMed=11831780; DOI=10.1111/j.1550-7408.2001.tb00211.x;
RA Shin H.-J., Cho M.-S., Jung S.-U., Kim H.-I., Park S., Kim H.-J., Im K.;
RT "Molecular cloning and characterization of a gene encoding a 13.1 kDa
RT antigenic protein of Naegleria fowleri.";
RL J. Eukaryot. Microbiol. 48:713-717(2001).
CC -!- FUNCTION: Oxygen-binding protein. The oxygen-binding site contains two
CC iron atoms (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the hemerythrin family. {ECO:0000305}.
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DR EMBL; AF230370; AAF35899.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9NH76; -.
DR SMR; Q9NH76; -.
DR VEuPathDB; AmoebaDB:FDP41_005547; -.
DR VEuPathDB; AmoebaDB:FDP41_010118; -.
DR VEuPathDB; AmoebaDB:NF0127030; -.
DR VEuPathDB; AmoebaDB:NfTy_067100; -.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProt.
DR CDD; cd12107; Hemerythrin; 1.
DR Gene3D; 1.20.120.50; -; 1.
DR InterPro; IPR002063; Haemerythrin.
DR InterPro; IPR016131; Haemerythrin_Fe_BS.
DR InterPro; IPR012312; Hemerythrin-like.
DR InterPro; IPR035938; Hemerythrin-like_sf.
DR InterPro; IPR012827; Hemerythrin_metal-bd.
DR Pfam; PF01814; Hemerythrin; 1.
DR PIRSF; PIRSF002033; Hemerythrin; 1.
DR PRINTS; PR00186; HEMERYTHRIN.
DR SUPFAM; SSF47188; SSF47188; 1.
DR TIGRFAMs; TIGR02481; hemeryth_dom; 1.
DR TIGRFAMs; TIGR00058; Hemerythrin; 1.
DR PROSITE; PS00550; HEMERYTHRINS; 1.
PE 3: Inferred from homology;
KW Iron; Metal-binding; Oxygen transport; Transport.
FT CHAIN 1..119
FT /note="Hemerythrin-like protein"
FT /id="PRO_0000191832"
FT BINDING 26
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 56
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 60
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 60
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 75
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 79
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 107
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 112
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P02244"
FT BINDING 112
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P02244"
SQ SEQUENCE 119 AA; 13403 MW; F3C1E40E9D1C0271 CRC64;
MATTIPSPFN WDSSFCVGNN ELNEQHKKLF ALINALDANR SSASALKELL DFVVMHFKAE
EDLFAKVNFS DSTSHKETHD KFVQDALGLK TVGDAEIQFI KQWLVNHIKG SDMKYKGVL
