ID   HEMTM_HEDDI             Reviewed;         120 AA.
AC   P22761;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Myohemerythrin;
DE            Short=MHr;
OS   Hediste diversicolor (Sandworm) (Nereis diversicolor).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Errantia; Phyllodocida; Nereididae; Hediste;
OC   Hediste diversicolor species group.
OX   NCBI_TaxID=126592;
RN   [1]
RP   PROTEIN SEQUENCE, AND TISSUE SPECIFICITY.
RC   TISSUE=Muscle;
RX   PubMed=2065779; DOI=10.1016/0014-5793(91)80716-g;
RA   Takagi T., Cox J.A.;
RT   "Primary structure of myohemerythrin from the annelid Nereis
RT   diversicolor.";
RL   FEBS Lett. 285:25-27(1991).
CC   -!- FUNCTION: Myohemerythrin is an oxygen-binding protein found in the
CC       retractor muscles of certain worms. The oxygen-binding site contains
CC       two iron atoms (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Muscle. {ECO:0000269|PubMed:2065779}.
CC   -!- SIMILARITY: Belongs to the hemerythrin family. {ECO:0000305}.
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DR   PIR; S16190; S16190.
DR   AlphaFoldDB; P22761; -.
DR   SMR; P22761; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProt.
DR   CDD; cd12107; Hemerythrin; 1.
DR   Gene3D; 1.20.120.50; -; 1.
DR   InterPro; IPR002063; Haemerythrin.
DR   InterPro; IPR016131; Haemerythrin_Fe_BS.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR035938; Hemerythrin-like_sf.
DR   InterPro; IPR012827; Hemerythrin_metal-bd.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   PIRSF; PIRSF002033; Hemerythrin; 1.
DR   PRINTS; PR00186; HEMERYTHRIN.
DR   SUPFAM; SSF47188; SSF47188; 1.
DR   TIGRFAMs; TIGR02481; hemeryth_dom; 1.
DR   TIGRFAMs; TIGR00058; Hemerythrin; 1.
DR   PROSITE; PS00550; HEMERYTHRINS; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Iron; Metal-binding; Muscle protein;
KW   Oxygen transport; Transport.
FT   CHAIN           1..120
FT                   /note="Myohemerythrin"
FT                   /id="PRO_0000191833"
FT   BINDING         25
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         54
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         58
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         58
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         75
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         79
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         108
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         113
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         113
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
SQ   SEQUENCE   120 AA;  13641 MW;  A793589D582E8B97 CRC64;
     GFEVPEPFKW DESFQVFYDK LDEEHKQIFN AIFALGGGNN ADNLKKMIDV TANHFADEEA
     MMLASAAYKS EHPGHKKKHE DFLAVIRGLS APVPNDKLLY AKDWLVNHIK GTDFTYKGKL