ID   HEMTM_SIPNU             Reviewed;         120 AA.
AC   Q5K473; A9JNT1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Myohemerythrin;
DE            Short=MHr;
DE            Short=myoHr;
OS   Sipunculus nudus (Marine worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Sipuncula; Sipunculidea;
OC   Golfingiida; Sipunculidae; Sipunculus.
OX   NCBI_TaxID=6446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2-120.
RA   Vanin S., Negrisolo E., Bailly X., Bubacco L., Beltramini M., Salvato B.;
RT   "Molecular evolution and phylogeny of Sipuculans hemerythrins.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-120.
RA   Bailly X., Vanin S., Chabasse C., Mizuguchi K., Vinogradov S.;
RT   "Are hemerythrins relics of evolution? A limited distribution in genomes
RT   from the three kingdoms of life.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myohemerythrin is an oxygen-binding protein found in the
CC       retractor muscles of certain worms. The oxygen-binding site contains
CC       two iron atoms (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hemerythrin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ632198; CAG14944.1; -; mRNA.
DR   EMBL; AM886445; CAP08292.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5K473; -.
DR   SMR; Q5K473; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProt.
DR   CDD; cd12107; Hemerythrin; 1.
DR   Gene3D; 1.20.120.50; -; 1.
DR   InterPro; IPR002063; Haemerythrin.
DR   InterPro; IPR016131; Haemerythrin_Fe_BS.
DR   InterPro; IPR012312; Hemerythrin-like.
DR   InterPro; IPR035938; Hemerythrin-like_sf.
DR   InterPro; IPR012827; Hemerythrin_metal-bd.
DR   Pfam; PF01814; Hemerythrin; 1.
DR   PIRSF; PIRSF002033; Hemerythrin; 1.
DR   PRINTS; PR00186; HEMERYTHRIN.
DR   SUPFAM; SSF47188; SSF47188; 1.
DR   TIGRFAMs; TIGR02481; hemeryth_dom; 1.
DR   TIGRFAMs; TIGR00058; Hemerythrin; 1.
DR   PROSITE; PS00550; HEMERYTHRINS; 1.
PE   2: Evidence at transcript level;
KW   Iron; Metal-binding; Muscle protein; Oxygen transport; Transport.
FT   CHAIN           1..120
FT                   /note="Myohemerythrin"
FT                   /id="PRO_0000343358"
FT   BINDING         26
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         56
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         60
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         60
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         75
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         79
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         108
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         113
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         113
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   CONFLICT        25
FT                   /note="K -> E (in Ref. 2; CAP08292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   120 AA;  13956 MW;  8308942E2375A8BC CRC64;
     MGFPIPDPYV WDESFKVFYQ LLDDKHKQIF QGVFDCAKDP SSAAKLQKLI EVTAKHFSDE
     ENMMQQSKYS GYPPHKKAHE EFLGKLRGLR APLDTAGLDY CKDWLVQHIK TIDFKYKGKL