HEMX_BACSU
ID HEMX_BACSU Reviewed; 276 AA.
AC P16645;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein HemX;
GN Name=hemX; OrderedLocusNames=BSU28160;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2110138; DOI=10.1128/jb.172.5.2250-2258.1990;
RA Petricek M., Rutberg L., Schroeder I., Hederstedt L.;
RT "Cloning and characterization of the hemA region of the Bacillus subtilis
RT chromosome.";
RL J. Bacteriol. 172:2250-2258(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969504; DOI=10.1099/13500872-142-11-3067;
RA Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J.,
RA Emmerson P.T., Harwood C.R.;
RT "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis
RT chromosome containing genes responsible for stress responses, the
RT utilization of plant cell walls and primary metabolism.";
RL Microbiology 142:3067-3078(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 162.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- FUNCTION: Required for HemL synthesis.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: To M.leprae U1620K. {ECO:0000305}.
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DR EMBL; M57676; AAA22511.1; -; Genomic_DNA.
DR EMBL; Z75208; CAA99544.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14776.2; -; Genomic_DNA.
DR PIR; B35252; B35252.
DR RefSeq; NP_390694.2; NC_000964.3.
DR RefSeq; WP_003222575.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P16645; -.
DR SMR; P16645; -.
DR STRING; 224308.BSU28160; -.
DR PaxDb; P16645; -.
DR PRIDE; P16645; -.
DR EnsemblBacteria; CAB14776; CAB14776; BSU_28160.
DR GeneID; 64304540; -.
DR GeneID; 937489; -.
DR KEGG; bsu:BSU28160; -.
DR PATRIC; fig|224308.179.peg.3059; -.
DR eggNOG; COG0755; Bacteria.
DR InParanoid; P16645; -.
DR OMA; VMLVNIF; -.
DR PhylomeDB; P16645; -.
DR BioCyc; BSUB:BSU28160-MON; -.
DR PRO; PR:P16645; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
PE 4: Predicted;
KW Cell membrane; Membrane; Porphyrin biosynthesis; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..276
FT /note="Protein HemX"
FT /id="PRO_0000083949"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 162
FT /note="L -> V (in Ref. 1; AAA22511 and 2; CAA99544)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 32051 MW; FC09E46989B945F7 CRC64;
MIDTAMARLN EGTIVIYALS VLFYFIDFLQ HNRKAGKMAF WLLSIVWTLQ TVYLAYFMWV
TGRFPVLNVT EALYFYAWVL VTLSLVLTKL LRVDFIVFFT NVIGFSMIAI HTFSPTEQQS
AAFSGQLVSE LLVIHITMAI LSYGAFSLSF VFSVLYMFQY HLLKKKKWGK WLLRIEDLSK
LDYMAYVLNV IGVPMLLLSL ILGVIWAYVS LETLYWFDAK VLGSFVVLLL YSYYLYIRLI
KELQGKVAAL WNTACFLVLM INYFLLGSLS QFHWFS
