ID   HEMX_BREBE              Reviewed;         272 AA.
AC   O69103;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Protein HemX;
GN   Name=hemX;
OS   Brevibacillus brevis (Bacillus brevis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=1393;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8246 / DSM 30 / JCM 2503 / NCIB 9372 / NCTC 2611;
RX   PubMed=10217486; DOI=10.1099/13500872-145-3-529;
RA   Johansson P., Hederstedt L.;
RT   "Organization of genes for tetrapyrrole biosynthesis in Gram-positive
RT   bacteria.";
RL   Microbiology 145:529-538(1999).
CC   -!- FUNCTION: Required for HemL synthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AF064059; AAC18580.1; -; Genomic_DNA.
DR   AlphaFoldDB; O69103; -.
DR   SMR; O69103; -.
DR   eggNOG; COG0755; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   PANTHER; PTHR30071; PTHR30071; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Porphyrin biosynthesis; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..272
FT                   /note="Protein HemX"
FT                   /id="PRO_0000083950"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   272 AA;  31643 MW;  7837FC196E50341A CRC64;
     MAEVRWIYDL TIFLYAASVL FYFNDFLQSN RKVNRLAFGL LVVVWALQTA FFVSQAVMKG
     YFPVITLFET LFFYSWVLVG LSLAIHYFFR IDLLVFLPNI IGFVVLVMSM FLPETPIEAV
     SSILTSELLL THVTLAMFSY GAFSLSMIFS AMYLLQHKML KGRRWSPLLR RLPSLDQLEG
     YAYRMNMLGV PMLLLSIVLG IIWGKMVLGE KFLLDSKVLL SELVLAIYSL WLYQRYRIRC
     RCADSSQWNV LAFLLLLINF LGFTTSTFHD WW