ID   HEMY_ECO57              Reviewed;         398 AA.
AC   P0ACB9; P09128;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Protein HemY;
GN   Name=hemY; OrderedLocusNames=Z5316, ECs4732;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC       {ECO:0000250}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AE005174; AAG58994.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38155.1; -; Genomic_DNA.
DR   PIR; D91220; D91220.
DR   PIR; F86066; F86066.
DR   RefSeq; NP_312759.1; NC_002695.1.
DR   RefSeq; WP_000921791.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACB9; -.
DR   SMR; P0ACB9; -.
DR   STRING; 155864.EDL933_5120; -.
DR   EnsemblBacteria; AAG58994; AAG58994; Z5316.
DR   EnsemblBacteria; BAB38155; BAB38155; ECs_4732.
DR   GeneID; 66672294; -.
DR   GeneID; 915180; -.
DR   KEGG; ece:Z5316; -.
DR   KEGG; ecs:ECs_4732; -.
DR   PATRIC; fig|386585.9.peg.4938; -.
DR   eggNOG; COG3071; Bacteria.
DR   HOGENOM; CLU_037501_2_0_6; -.
DR   OMA; WGKARDY; -.
DR   UniPathway; UPA00252; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR   InterPro; IPR010817; HemY_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF07219; HemY_N; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR00540; TPR_hemY_coli; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Porphyrin biosynthesis;
KW   Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..398
FT                   /note="Protein HemY"
FT                   /id="PRO_0000135276"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..39
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..398
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          118..151
FT                   /note="TPR 1"
FT   REPEAT          328..361
FT                   /note="TPR 2"
SQ   SEQUENCE   398 AA;  45245 MW;  56BDDC4E19099D3C CRC64;
     MLKVLLLFVL LIAGIVVGPM IAGHQGYVLI QTDNYNIETS VTGLAIILIL AMVVLFAIEW
     LLRRIFRTGA HTRGWFVGRK RRRARKQTEQ ALLKLAEGDY QQVEKLMAKN ADHAEQPVVN
     YLLAAEAAQQ RGDEARANQH LERAAELAGN DTIPVEITRV RLQLARNENH AARHGVDKLL
     EVTPRHPEVL RLAEQAYIRT GAWSSLLDII PSMAKAHVGD EEHRAMLEQQ AWIGLMDQAR
     ADNGSEGLRN WWKNQSRKTR HQVALQVAMA EHLIECDDHD TAQQIIIDGL KRQYDDRLLL
     PIPRLKTNNP EQLEKVLRQQ IKNVGDRPLL WSTLGQSLMK HGEWQEASLA FRAALKQRPD
     AYDYAWLADA LDRLHKPEEA AAMRRDGLML TLQNNPPQ