HEMY_ECOLI
ID HEMY_ECOLI Reviewed; 398 AA.
AC P0ACB7; P09128; Q2M8A7;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein HemY;
GN Name=hemY; OrderedLocusNames=b3802, JW3774;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / CS520;
RX PubMed=3054815; DOI=10.1093/nar/16.20.9871;
RA Alefounder P.R., Abell C., Battersby A.R.;
RT "The sequence of hemC, hemD and two additional E. coli genes.";
RL Nucleic Acids Res. 16:9871-9871(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=1379743; DOI=10.1126/science.1379743;
RA Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
RT "Analysis of the Escherichia coli genome: DNA sequence of the region from
RT 84.5 to 86.5 minutes.";
RL Science 257:771-778(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
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DR EMBL; X12614; CAA31135.1; -; Genomic_DNA.
DR EMBL; M87049; AAA67598.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76805.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77499.1; -; Genomic_DNA.
DR PIR; S01694; S01694.
DR RefSeq; NP_418246.1; NC_000913.3.
DR RefSeq; WP_000921791.1; NZ_STEB01000021.1.
DR AlphaFoldDB; P0ACB7; -.
DR SMR; P0ACB7; -.
DR BioGRID; 4262608; 183.
DR DIP; DIP-47881N; -.
DR IntAct; P0ACB7; 3.
DR STRING; 511145.b3802; -.
DR jPOST; P0ACB7; -.
DR PaxDb; P0ACB7; -.
DR PRIDE; P0ACB7; -.
DR EnsemblBacteria; AAC76805; AAC76805; b3802.
DR EnsemblBacteria; BAE77499; BAE77499; BAE77499.
DR GeneID; 66672294; -.
DR GeneID; 948311; -.
DR KEGG; ecj:JW3774; -.
DR KEGG; eco:b3802; -.
DR PATRIC; fig|1411691.4.peg.2906; -.
DR EchoBASE; EB0429; -.
DR eggNOG; COG3071; Bacteria.
DR HOGENOM; CLU_037501_2_0_6; -.
DR InParanoid; P0ACB7; -.
DR OMA; WGKARDY; -.
DR PhylomeDB; P0ACB7; -.
DR BioCyc; EcoCyc:EG10434-MON; -.
DR UniPathway; UPA00252; -.
DR PRO; PR:P0ACB7; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR00540; TPR_hemY_coli; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Porphyrin biosynthesis;
KW Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..398
FT /note="Protein HemY"
FT /id="PRO_0000135275"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..39
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 118..151
FT /note="TPR 1"
FT REPEAT 328..361
FT /note="TPR 2"
SQ SEQUENCE 398 AA; 45245 MW; 56BDDC4E19099D3C CRC64;
MLKVLLLFVL LIAGIVVGPM IAGHQGYVLI QTDNYNIETS VTGLAIILIL AMVVLFAIEW
LLRRIFRTGA HTRGWFVGRK RRRARKQTEQ ALLKLAEGDY QQVEKLMAKN ADHAEQPVVN
YLLAAEAAQQ RGDEARANQH LERAAELAGN DTIPVEITRV RLQLARNENH AARHGVDKLL
EVTPRHPEVL RLAEQAYIRT GAWSSLLDII PSMAKAHVGD EEHRAMLEQQ AWIGLMDQAR
ADNGSEGLRN WWKNQSRKTR HQVALQVAMA EHLIECDDHD TAQQIIIDGL KRQYDDRLLL
PIPRLKTNNP EQLEKVLRQQ IKNVGDRPLL WSTLGQSLMK HGEWQEASLA FRAALKQRPD
AYDYAWLADA LDRLHKPEEA AAMRRDGLML TLQNNPPQ