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HEMY_ECOLI
ID   HEMY_ECOLI              Reviewed;         398 AA.
AC   P0ACB7; P09128; Q2M8A7;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Protein HemY;
GN   Name=hemY; OrderedLocusNames=b3802, JW3774;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / CS520;
RX   PubMed=3054815; DOI=10.1093/nar/16.20.9871;
RA   Alefounder P.R., Abell C., Battersby A.R.;
RT   "The sequence of hemC, hemD and two additional E. coli genes.";
RL   Nucleic Acids Res. 16:9871-9871(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=1379743; DOI=10.1126/science.1379743;
RA   Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome: DNA sequence of the region from
RT   84.5 to 86.5 minutes.";
RL   Science 257:771-778(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
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DR   EMBL; X12614; CAA31135.1; -; Genomic_DNA.
DR   EMBL; M87049; AAA67598.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76805.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77499.1; -; Genomic_DNA.
DR   PIR; S01694; S01694.
DR   RefSeq; NP_418246.1; NC_000913.3.
DR   RefSeq; WP_000921791.1; NZ_STEB01000021.1.
DR   AlphaFoldDB; P0ACB7; -.
DR   SMR; P0ACB7; -.
DR   BioGRID; 4262608; 183.
DR   DIP; DIP-47881N; -.
DR   IntAct; P0ACB7; 3.
DR   STRING; 511145.b3802; -.
DR   jPOST; P0ACB7; -.
DR   PaxDb; P0ACB7; -.
DR   PRIDE; P0ACB7; -.
DR   EnsemblBacteria; AAC76805; AAC76805; b3802.
DR   EnsemblBacteria; BAE77499; BAE77499; BAE77499.
DR   GeneID; 66672294; -.
DR   GeneID; 948311; -.
DR   KEGG; ecj:JW3774; -.
DR   KEGG; eco:b3802; -.
DR   PATRIC; fig|1411691.4.peg.2906; -.
DR   EchoBASE; EB0429; -.
DR   eggNOG; COG3071; Bacteria.
DR   HOGENOM; CLU_037501_2_0_6; -.
DR   InParanoid; P0ACB7; -.
DR   OMA; WGKARDY; -.
DR   PhylomeDB; P0ACB7; -.
DR   BioCyc; EcoCyc:EG10434-MON; -.
DR   UniPathway; UPA00252; -.
DR   PRO; PR:P0ACB7; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR   InterPro; IPR010817; HemY_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF07219; HemY_N; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR00540; TPR_hemY_coli; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Porphyrin biosynthesis;
KW   Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..398
FT                   /note="Protein HemY"
FT                   /id="PRO_0000135275"
FT   TOPO_DOM        1..4
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..39
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..398
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          118..151
FT                   /note="TPR 1"
FT   REPEAT          328..361
FT                   /note="TPR 2"
SQ   SEQUENCE   398 AA;  45245 MW;  56BDDC4E19099D3C CRC64;
     MLKVLLLFVL LIAGIVVGPM IAGHQGYVLI QTDNYNIETS VTGLAIILIL AMVVLFAIEW
     LLRRIFRTGA HTRGWFVGRK RRRARKQTEQ ALLKLAEGDY QQVEKLMAKN ADHAEQPVVN
     YLLAAEAAQQ RGDEARANQH LERAAELAGN DTIPVEITRV RLQLARNENH AARHGVDKLL
     EVTPRHPEVL RLAEQAYIRT GAWSSLLDII PSMAKAHVGD EEHRAMLEQQ AWIGLMDQAR
     ADNGSEGLRN WWKNQSRKTR HQVALQVAMA EHLIECDDHD TAQQIIIDGL KRQYDDRLLL
     PIPRLKTNNP EQLEKVLRQQ IKNVGDRPLL WSTLGQSLMK HGEWQEASLA FRAALKQRPD
     AYDYAWLADA LDRLHKPEEA AAMRRDGLML TLQNNPPQ
 
 
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