HEMY_HAEIN
ID HEMY_HAEIN Reviewed; 428 AA.
AC P44772;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein HemY homolog;
GN Name=hemY; OrderedLocusNames=HI_0602;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000250}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
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DR EMBL; L42023; AAC22260.1; -; Genomic_DNA.
DR PIR; C64080; C64080.
DR RefSeq; NP_438760.1; NC_000907.1.
DR RefSeq; WP_005694537.1; NC_000907.1.
DR AlphaFoldDB; P44772; -.
DR SMR; P44772; -.
DR STRING; 71421.HI_0602; -.
DR PRIDE; P44772; -.
DR EnsemblBacteria; AAC22260; AAC22260; HI_0602.
DR KEGG; hin:HI_0602; -.
DR PATRIC; fig|71421.8.peg.625; -.
DR eggNOG; COG3071; Bacteria.
DR HOGENOM; CLU_037501_2_0_6; -.
DR OMA; WGKARDY; -.
DR PhylomeDB; P44772; -.
DR BioCyc; HINF71421:G1GJ1-621-MON; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF07219; HemY_N; 1.
DR TIGRFAMs; TIGR00540; TPR_hemY_coli; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Porphyrin biosynthesis;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..428
FT /note="Protein HemY homolog"
FT /id="PRO_0000135278"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 408..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48776 MW; 8654FAC94689CB5C CRC64;
MFRVLFLMLT LLVGLVAGPY ISGQQGYVRI ETANRIIEMS ITTLVIFFII SLAIIYAFEW
GVTRFFRLSR SSYQWFSNRK RVKAQKQTLE GLVKMDEGDY AKAEKLIGKN AKHSAEPVLN
LIKAAEAAQQ RGDEFSANRY LIEATELAGS DNLLVEIART RILLQQNKLP AARSSVDSLL
EMARRNKEVL KLAVEIYLRS KAYQALDKIL DNVANSGLFN DEEFKDLRSK TENGLLDEKM
NEEGIDGLLT WWNQQPRHRR NNIELKISLI QRLIDCNDHE SATELTFEIL KKLGDNTAIS
LPLCTQITRL QPEDNSKLLK LIEKRAKRVD EKQKCCINRA LGYLYVRNNE FIKAADVFKN
VIACPEQLEQ NDLMMASYVF EQAGDKALAE QVRQESLKSV MAIQDVIPES AEEKTEENST
ALLESKSE
