HEMY_SHIFL
ID HEMY_SHIFL Reviewed; 398 AA.
AC P0ACC0; P09128;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Protein HemY;
GN Name=hemY; OrderedLocusNames=SF3874, S3882;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000250}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
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DR EMBL; AE005674; AAN45311.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18887.1; -; Genomic_DNA.
DR RefSeq; NP_709604.1; NC_004337.2.
DR RefSeq; WP_000921791.1; NZ_WPGW01000140.1.
DR AlphaFoldDB; P0ACC0; -.
DR SMR; P0ACC0; -.
DR STRING; 198214.SF3874; -.
DR EnsemblBacteria; AAN45311; AAN45311; SF3874.
DR EnsemblBacteria; AAP18887; AAP18887; S3882.
DR GeneID; 1026713; -.
DR GeneID; 66672294; -.
DR KEGG; sfl:SF3874; -.
DR KEGG; sfx:S3882; -.
DR PATRIC; fig|198214.7.peg.4569; -.
DR HOGENOM; CLU_037501_2_0_6; -.
DR OMA; WGKARDY; -.
DR OrthoDB; 699592at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR00540; TPR_hemY_coli; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Porphyrin biosynthesis;
KW Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..398
FT /note="Protein HemY"
FT /id="PRO_0000135279"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..39
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 118..151
FT /note="TPR 1"
FT REPEAT 328..361
FT /note="TPR 2"
SQ SEQUENCE 398 AA; 45245 MW; 56BDDC4E19099D3C CRC64;
MLKVLLLFVL LIAGIVVGPM IAGHQGYVLI QTDNYNIETS VTGLAIILIL AMVVLFAIEW
LLRRIFRTGA HTRGWFVGRK RRRARKQTEQ ALLKLAEGDY QQVEKLMAKN ADHAEQPVVN
YLLAAEAAQQ RGDEARANQH LERAAELAGN DTIPVEITRV RLQLARNENH AARHGVDKLL
EVTPRHPEVL RLAEQAYIRT GAWSSLLDII PSMAKAHVGD EEHRAMLEQQ AWIGLMDQAR
ADNGSEGLRN WWKNQSRKTR HQVALQVAMA EHLIECDDHD TAQQIIIDGL KRQYDDRLLL
PIPRLKTNNP EQLEKVLRQQ IKNVGDRPLL WSTLGQSLMK HGEWQEASLA FRAALKQRPD
AYDYAWLADA LDRLHKPEEA AAMRRDGLML TLQNNPPQ
