HEN1_MOUSE
ID HEN1_MOUSE Reviewed; 133 AA.
AC Q02576;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Helix-loop-helix protein 1;
DE Short=HEN-1;
DE AltName: Full=Nescient helix loop helix 1;
DE Short=NSCL-1;
GN Name=Nhlh1; Synonyms=Hen1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1528853; DOI=10.1073/pnas.89.18.8492;
RA Brown L., Espinosa R. III, le Beau M.M., Siciliano M.J., Baer R.;
RT "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are
RT coexpressed in a human neuroblastoma.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8492-8496(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1729708; DOI=10.1073/pnas.89.1.38;
RA Begley C.G., Lipkowitz S., Gobel V., Mahon K.A., Bertness V., Green A.R.,
RA Gough N.M., Kirsch I.R.;
RT "Molecular characterization of NSCL, a gene encoding a helix-loop-helix
RT protein expressed in the developing nervous system.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:38-42(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May serve as DNA-binding protein and may be involved in the
CC control of cell-type determination, possibly within the developing
CC nervous system.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; M97506; AAA37801.1; -; Genomic_DNA.
DR EMBL; M82874; AAA39840.1; -; mRNA.
DR EMBL; BC051018; AAH51018.1; -; mRNA.
DR CCDS; CCDS15506.1; -.
DR PIR; A41788; A41788.
DR RefSeq; NP_035046.1; NM_010916.2.
DR AlphaFoldDB; Q02576; -.
DR SMR; Q02576; -.
DR STRING; 10090.ENSMUSP00000057489; -.
DR PhosphoSitePlus; Q02576; -.
DR PaxDb; Q02576; -.
DR PRIDE; Q02576; -.
DR Antibodypedia; 34277; 154 antibodies from 24 providers.
DR DNASU; 18071; -.
DR Ensembl; ENSMUST00000059794; ENSMUSP00000057489; ENSMUSG00000051251.
DR GeneID; 18071; -.
DR KEGG; mmu:18071; -.
DR UCSC; uc007dpj.2; mouse.
DR CTD; 4807; -.
DR MGI; MGI:98481; Nhlh1.
DR VEuPathDB; HostDB:ENSMUSG00000051251; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000162622; -.
DR HOGENOM; CLU_148882_1_0_1; -.
DR InParanoid; Q02576; -.
DR OMA; MLNSDQT; -.
DR PhylomeDB; Q02576; -.
DR BioGRID-ORCS; 18071; 7 hits in 76 CRISPR screens.
DR ChiTaRS; Henmt1; mouse.
DR PRO; PR:Q02576; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q02576; protein.
DR Bgee; ENSMUSG00000051251; Expressed in cerebellar layer and 61 other tissues.
DR Genevisible; Q02576; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040238; TAL-like.
DR PANTHER; PTHR13864; PTHR13864; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..133
FT /note="Helix-loop-helix protein 1"
FT /id="PRO_0000127198"
FT DOMAIN 75..127
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 133 AA; 14830 MW; 49D4118F67ECAD07 CRC64;
MMLNSDTMEL DLPPTHSETE SGFSDCGGGP GPDGAGSGDP GVVQVRSSEL GESGRKDLQH
LSREERRRRR RATAKYRTAH ATRERIRVEA FNLAFAELRK LLPTLPPDKK LSKIEILRLA
ICYISYLNHV LDV
