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HEPA_BHV1C
ID   HEPA_BHV1C              Reviewed;         748 AA.
AC   P52374;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 50.
DE   RecName: Full=DNA helicase/primase complex-associated protein {ECO:0000255|HAMAP-Rule:MF_04010};
DE            Short=HEPA {ECO:0000255|HAMAP-Rule:MF_04010};
DE   AltName: Full=Primase-associated factor {ECO:0000255|HAMAP-Rule:MF_04010};
GN   Name=UL8;
OS   Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine
OS   rhinotracheitis virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10323;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7793062; DOI=10.1006/viro.1995.1321;
RA   Vlcek C., Benes V., Lu Z., Kutish G.F., Paces V., Rock D., Letchworth G.J.,
RA   Schwyzer M.;
RT   "Nucleotide sequence analysis of a 30-kb region of the bovine herpesvirus 1
RT   genome which exhibits a colinear gene arrangement with the UL21 to UL4
RT   genes of herpes simplex virus.";
RL   Virology 210:100-108(1995).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase. {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_04010}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
CC       {ECO:0000255|HAMAP-Rule:MF_04010}.
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DR   EMBL; Z48053; CAA88125.1; -; Genomic_DNA.
DR   PIR; S61247; S61247.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_04010; HSV_HEPA; 1.
DR   InterPro; IPR004996; HSV_HEPA.
DR   Pfam; PF03324; Herpes_HEPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Host nucleus.
FT   CHAIN           1..748
FT                   /note="DNA helicase/primase complex-associated protein"
FT                   /id="PRO_0000115858"
SQ   SEQUENCE   748 AA;  78994 MW;  3B176AD7A2ABBFD5 CRC64;
     MPVSHSNGCV CGVSLYSAWA AGPDRARVLL ALLCRMDDGG CDAKFALVNV CARGVTALAR
     GARDVTAARL EDLARAAAAP RALPLATLGH AATWKALYVS ALAACARRLG PFAFIERRAL
     EETTDTGLLV SAEEPPDAAD AAPRAAVLRS ALRLAVEEDA VRAAAAAAPA GGGSLARARL
     CAMRDGHADL SAPGNVVEFE LTTKTARFYR IFADIAQPPR KRAGRLADVF AHREYRVRTE
     GSAAPVVVRA LVPVNFDCVV ADARAFSPMA AMLVFAQWHA ALFTDGPAQV LGFLGPQLNP
     GGEERDYCFL LGFPGVPLVV SAADAGAVRD DLDAHVLTDG LWPAFGVHVY HALGPWNFLD
     GAAVASLNRR IAAARAALPP GGSDGSDWPA GRVSTILNSP ARARGSGWPR FDFSAFFPTL
     YAHLVPENAR LARAICARRD GRPGLKPSLL TFFGGLRHVH APAYEAVIAL ANAVAAAVER
     AANARNFAVC TYVKDGFWGA FGDAAPEVVP REAALAAALA LRDDCQRAAE AVLRAAGLHP
     AEGAELHLRF EGLFTHAVSW SANKYWLWDA TAGGAEGELF VGFPCRTEFG RMAKRSLAGL
     LRRAVAQPER PSDTVAAAAA ACDALVHAAF ERRGDVRFWS ATAPIADWGA VPRSALSGGD
     LLDADHGPRP YVLVAGHEAA PFPLPWGSLP LPVLLPDIAC RAHMAPVLQE LARMLNGALA
     ALAAREGDDE PPIEEFEYNL ADFDFLFA
 
 
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