ID   HEPA_GAHVM              Reviewed;         769 AA.
AC   Q9E6Q8;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-DEC-2020, entry version 54.
DE   RecName: Full=DNA helicase/primase complex-associated protein {ECO:0000255|HAMAP-Rule:MF_04010};
DE            Short=HEPA {ECO:0000255|HAMAP-Rule:MF_04010};
DE   AltName: Full=Primase-associated factor {ECO:0000255|HAMAP-Rule:MF_04010};
GN   Name=MDV020;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase. {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_04010}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
CC       {ECO:0000255|HAMAP-Rule:MF_04010}.
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DR   EMBL; AF243438; AAG14200.1; -; Genomic_DNA.
DR   RefSeq; YP_001033936.1; NC_002229.3.
DR   GeneID; 4811481; -.
DR   KEGG; vg:4811481; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_04010; HSV_HEPA; 1.
DR   InterPro; IPR004996; HSV_HEPA.
DR   Pfam; PF03324; Herpes_HEPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Host nucleus; Reference proteome.
FT   CHAIN           1..769
FT                   /note="DNA helicase/primase complex-associated protein"
FT                   /id="PRO_0000406581"
SQ   SEQUENCE   769 AA;  86908 MW;  283089BDBAF08333 CRC64;
     MRQTISTMAA SSKTNMMQIM RGCICYTTVY RIWTNKNRTE GLTALCYLLF RNTCGQYSAQ
     YSTVNLSGKS MAKLWGLNPD MITDTMLAGM TNSASVTGLW PSCPSDQHML WKALLTTTLA
     KLRHRLGYHA YYTPVTIYID SQTGLVTACE PVSGERSIPR PGLLKTDGMI SVEESCLIST
     AMKHAEGAPL AHIKLSALKR TRQIPEFDMR IEIQTKEERF LREYKKVNSP YKKFKCDNNS
     NTIFKVVDNT LVLDHLQPPV RALSLVPTSF DCLVTTPAEF SLVALLATYA KWHEKLYSCD
     NESTNILVPI LMYIGPETNP RGEDVDYSCI IGFPGWPIVK SSTANQTAIK DAIDAYVDTD
     GLWPLAGPRT FHLLAPWSPE NHPFPMIDTS HILSVHSTDI RHKAADEWTT GRITCILRDP
     TLIENAAIAK FDFSAFFATL YLGLFPTHSR LHDVVKARLK REKPWLKRPI LEFGGLLKKL
     NEDVYQSIIS IGNHISIEVE ATASSLMFAP CTYIKDGMWG TFMDKSKNVP RPPMDDERDF
     NILRNACAES ANNFAATIGL QFPDEILLDL RLEGIYTHAM SWNANCYWLW NKSNHHKDFV
     GFPNQPRFAS YAKHGLSTLL EKICISNDTD ESLQTVREKT HEVFEELLSI AFDHRSDVSF
     WSCPTELYDD TQYIAALGMK AAARFDTSGF NRETVQTVTA DGKIVSVTCS LFEGEIILPA
     IDCIDYMKPI LAAFSRLLIN VLSSKWDNVN RDDFTFDIES YRFMFINNK