ID   HEPA_HCMVM              Reviewed;         873 AA.
AC   F5HIG1;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 27.
DE   RecName: Full=DNA helicase/primase complex-associated protein {ECO:0000255|HAMAP-Rule:MF_04010};
DE            Short=HEPA {ECO:0000255|HAMAP-Rule:MF_04010};
DE   AltName: Full=Primase-associated factor {ECO:0000255|HAMAP-Rule:MF_04010};
GN   Name=UL102;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase. {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_04010}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
CC       {ECO:0000255|HAMAP-Rule:MF_04010}.
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DR   EMBL; AY446894; AAR31652.1; -; Genomic_DNA.
DR   RefSeq; YP_081548.1; NC_006273.2.
DR   PRIDE; F5HIG1; -.
DR   GeneID; 3077548; -.
DR   KEGG; vg:3077548; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_04010; HSV_HEPA; 1.
DR   InterPro; IPR004996; HSV_HEPA.
DR   Pfam; PF03324; Herpes_HEPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Host nucleus; Reference proteome.
FT   CHAIN           1..873
FT                   /note="DNA helicase/primase complex-associated protein"
FT                   /id="PRO_0000418266"
FT   REGION          394..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..420
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  94080 MW;  844F50617EBB045F CRC64;
     MTAQPPLHHR HHPYTLFGTS CHLSWYGLLE ASVPIVQCLF LDLGGGRAEP RLHTFVVRGD
     RLPPAEVRAV HRASYAALAS AVTTDADERR RGLEQRSAVL ARVLLEGSAL IRVLARTFTP
     VQIQTDASGV EILEAAPALG VETTALSNAL SLFHVAKLVV IGSYPEVHEP RVVTHAAERV
     SEEYGTHAHK KLRRGYYAYD LAMSFRVGTH KYVLERDDEA VLARLFEVRE VCFLRTCLRL
     VTPVGFVAVA VTDEQCCLLL QSAWTHLYDV LFRGFAGQPP LRDYLGPDLF ETGAARSFFF
     PGFPPVPVYA VHGLHTLMRE TALDAAAEVL SWCGLPDIVG SAGKLEVEPC ALSLGVPEDE
     WQVFGTEAGG GAVRLNATAF RERPAGGDRR WLLPPLPRDD GDGENNVVEV SSSTGGAHPP
     SDDATFTVHV RDATLHRVLI VDLVERVLAK CVRARDFNPY VRYSHRLHTY AVCEKFIENL
     RFRSRRAFWQ IQSLLGYISE HVTSACASAG LLWVLSRGHR EFYVYDGYSG HGPVSAEVCV
     RTVVDCYWRK LFGGDDPGPT CRVQESAPGV LLVWGDERLV GPFNFFYGNG GAGGSPLHGV
     VGGFAAGHCG GACCAGCVVT HRHSSGGGGS GVGDADHASG GGLDAAAGSG HNGGSDRVSP
     STPPAALGGC CCAAGGDWLS AVGHVLGRLP ALLRERVSVS ELEAVYREIL FRFVARRNDV
     DFWLLRFQPG ENEVRPHAGV IDCAPFHGVW AEQGQIIVQS RDTALAADIG YGVYVDKAFA
     MLTACVEVWA RELLSSSTAS TTTCSSSSVL SSALPSVTSS SSGTATVSPP SCSSSSATWL
     EERDEWVRSL AVDAQHAAKR VASEGLRFFR LNA