ID   HEPA_HHV6U              Reviewed;         662 AA.
AC   P52375;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-JUN-2021, entry version 63.
DE   RecName: Full=DNA helicase/primase complex-associated protein {ECO:0000255|HAMAP-Rule:MF_04010};
DE            Short=HEPA {ECO:0000255|HAMAP-Rule:MF_04010};
DE   AltName: Full=Primase-associated factor {ECO:0000255|HAMAP-Rule:MF_04010};
GN   Name=U74; Synonyms=HDRF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7941342; DOI=10.1006/viro.1994.1589;
RA   Nicholas J.;
RT   "Nucleotide sequence analysis of a 21-kbp region of the genome of human
RT   herpesvirus-6 containing homologues of human cytomegalovirus major
RT   immediate-early and replication genes.";
RL   Virology 204:738-750(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase. {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_04010}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
CC       {ECO:0000255|HAMAP-Rule:MF_04010}.
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DR   EMBL; U13194; AAA68465.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58366.1; -; Genomic_DNA.
DR   RefSeq; NP_042967.1; NC_001664.2.
DR   PRIDE; P52375; -.
DR   DNASU; 1487955; -.
DR   GeneID; 1487955; -.
DR   KEGG; vg:1487955; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_04010; HSV_HEPA; 1.
DR   InterPro; IPR004996; HSV_HEPA.
DR   Pfam; PF03324; Herpes_HEPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Host nucleus; Reference proteome.
FT   CHAIN           1..662
FT                   /note="DNA helicase/primase complex-associated protein"
FT                   /id="PRO_0000115861"
SQ   SEQUENCE   662 AA;  76316 MW;  2E29BBAF108F7621 CRC64;
     MHLRGCACHL SLYCVYNDWE NKIYRVPIFQ CLFLEAETRS LKTFLIRGQS LDQESLNEIE
     VTRKETMLWD LQEQSNMMDK KIAAISNLIM NNGELVRTLS KFFVPLTVVL GDDGLEILEA
     YVCGEELMLP LDTVPVILRC IGDYAALDTK HLLSNECTQA SKKIRFGYSV MDFHFSLTVS
     DVKICFSHTD TGEAVCEKMK QIFSFSVCAF GGEQVLLVTP KNAYALLFDD DLCLLLLQSV
     FAFLHEKIFG VYKQVLVQLC EYIGPDLWPF GNERSVSFIG YPNLWLLSVS DLERRVPDTT
     YICREILSFC GLAPILGPRG RHAVPVVREL SIEMPGSETS LQRFRFNSQY VSSESLCFQT
     GPEDTHLFFS DSDMYVVTLP DCLRLLLKST VPKAFLPCFD ENATEIDLLL KFMSRLQHRS
     YALFDAVIFM LDAFVSAFQR ACTLMGMRWL LVRDLHMFYL TCDGKDTHVV MPLLQTAVEN
     CWEKTTEIKQ RPTFQCAEIS RCGFIVYARF FLSSGLSQSK EAHWTVTASK YLSACIRTNK
     TGLCFASITV YFQDMMCVFI ANRYNVSYWI EEFDPNDYCL EYHEGLLDCS RYTAVMSEDG
     QLVRQARGIA LTDKINFSYY ILVTLRVLRR WVESKFEDVE QTQFIRWENR MLCEHIHLLH
     LN