ID   HEPA_PSHV1              Reviewed;         648 AA.
AC   Q6UDH2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=DNA helicase/primase complex-associated protein {ECO:0000255|HAMAP-Rule:MF_04010};
DE            Short=HEPA {ECO:0000255|HAMAP-Rule:MF_04010};
DE   AltName: Full=Primase-associated factor {ECO:0000255|HAMAP-Rule:MF_04010};
GN   Name=UL8;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase. {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_04010}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04010}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
CC       {ECO:0000255|HAMAP-Rule:MF_04010}.
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DR   EMBL; AY372243; AAQ73738.1; -; Genomic_DNA.
DR   RefSeq; NP_944432.1; NC_005264.1.
DR   GeneID; 2656975; -.
DR   KEGG; vg:2656975; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_04010; HSV_HEPA; 1.
DR   InterPro; IPR004996; HSV_HEPA.
PE   3: Inferred from homology;
KW   DNA replication; Host nucleus; Reference proteome.
FT   CHAIN           1..648
FT                   /note="DNA helicase/primase complex-associated protein"
FT                   /id="PRO_0000406835"
FT   REGION          43..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  70885 MW;  7DBC94547398BF39 CRC64;
     MRMRSLSAAS SGYNGDPRGL GLERLKTVVR GKLRPSGSEI EWLWPSDQNN TASPAGAKTD
     QPTSAPRFFL TREATVFGPS WKPASRQIVA SVLPVTGEMV MVSAERFSCM ALFAVFLKLY
     RGFYMKPVAP CATHVRRPIM LAQFPVFDSR PSHGPQEQSG SHEPLARAAA QRRTKHNFLF
     MPGFPCLACV PISASAERHD RAMAACRAAS LTEHLWPAYG IRALHMLNRT PAAASITRAV
     ARRSRLLTAD LTRSLETFPA GTITCAAGAP MIFSDCRLAR LDFSAFYPCL YAAYVGKHRG
     LTKILHERLR RRAGSEDLKP ALVTMFGGLR HVDANGYRFV VGASNIIAKA VEQTANRMGF
     GVAAYVKDGF WGAFDSSSKT TAEELRAECE KAANATLARL VVDKDGAGEP PVSLVLRLEG
     VYTDGLLINA NKYWLFNSES GDSFICGVMG GHERSGLSRE TTAAADDILK KIKASAKSID
     DVEAIARSRI DAWIYAIFGH RGDVEFWAEQ TPGDKDFLIP EEIRTTTVGK LEAADSCLGG
     ELSYVFIPKN TQDTGAAKTK GGGARGWHSA PAAAFPCSLV EDVFCIKINY EAHLLPRLEG
     LLAWSRIYAW LQFRNQIPLA DDEDESTTQA KETARIDYNY GDVSFLFA